The Mental health and Diabetes questionnaire is an additional questionnaire among adult Lifelines participants. The digital questionnaire was developed at the initiative of researchers from University of Tübingen and Carleton University. The study aims to identify if the combination of parental T2D and parental depression history increases the risk of T2D in their offspring. In this context, depression and stress resilience of the children is studied as well.

The collected MHDQ data is currently under embargo. Please contact the Lifelines data managers at data@lifelines.nl for more information.

Between May 22nd and June 7th 2023, a digital questionnaire was sent out to ~16 800 adult Lifelines participants, aged ≥30, without Type 2 Diabetes and with at least one parent who actively participates in Lifelines. Approximately ~4 300 participants (26%) responded.
Between July 3rd and July 20th 2023, ~5 300 parents of those participants were invited to fill in a shortened version of the questionnaire. Approximately ~3 300 parents responeded (62%).

The MHDQ questionnaire (for adult children) contained the following instruments:

• Secure Flourish Index (SFI): measures various domains of well-being. Translated by Lifelines.
• The Long-term Difficulties Inventory (LDI): measures long-term difficulties.
• The List of Threatening Experiences (LTE): measures the occurrence of 12 major categories of stressful life events.
• Lifetime Depression Assessment Self-Report (LIDAS): identifies persons who have or have not been depressed in their lifetime.
• MIDUS: questions about the relationship with your parents while growing up. This questionnaire was not validated and translated by Lifelines.
• Family environment: questions about family and household while growing up. This questionnaire was not validated and translated by Lifelines.

The MHDQ questionnaire for parents contained:

• Lifetime Depression Assessment Self-Report (LIDAS): identifies persons who have or have not been depressed in their lifetime.
• Diabetes and depression history: ad hoc questions to assess diabetes and depression in the participant and their spouse.

In addition to the questions listed above, the questionnaire for children also included the CD-RISC scale to assess resilience (Connor & Davidson 2003). This data remains under embargo. For questions about the conditions for reuse, please contact the Lifelines research office research@lifelines.nl.

• Anthropometry (self-reported) (2 items)
• Depression & Anxiety (LIDAS) (71 items)
• Diabetes (4 items)
• Familial diabetes (7 items)
• Familial mental illnesses (8 items)
• Family composition (1 item)
• Household composition (7 items)
• Medication (1 item)
• Mental illnesses (15 items)
• Parental bonding (MIDUS) (14 items)
• Personal data (5 items)
• Resilience (CD-RISC) (10 items): see statement above
• Secure Flourish Index (SFI) (12 items)
• Stress (LDI) (12 items)
• Stress (LTE) (18 items)
• Treatment (general (28 items)