Urine Sample Analyses
The following variables were assessed in fresh urine samples collected from Lifelines participants during 1A Visit 2 and 2A Visit 2 (section: physical state).
Assessments were performed at the laboratory center of the University Medical Center Groningen that is certified according to NEN-EN-ISO 9001:2008 and NEN-EN-ISO 15189:2012 standards.
For more information about individual assays, see here.
Note that additional analyses were performed on blood samples collected on the same day.
Assessments
Creatinine in the urine together with urine flow rate and creatinine levels in the blood can be used to calculate the creatinine clearance rate; the measurement is performed using a Roche Enzymatic assay with a detection limit of 0,097 - 45 mmol/L (predilution factor 20), traceable to reference isotope dilution mass spectroscopy.
Albumin was determined using Tinaquant turbidimetric assay (Roche) to determine Proteinuria – a marker suggestive of illness e.g. kidney injury.
| English | Code | Variable | N @ 1A | N @ 2A | N @ 3A | N @ 4A | Age |
| the 24h urine sample was obtained within 24h (before or after) the blood sample | ur24h_blood_all_m_1 | 24H_BL | ~131k | ~99k | ~78k | 100+ | 18+ |
| the 24h urine sample was obtained within 24h (before or after) the early morning spot urine sample | ur24h_uems_all_m_1 | 24H_EMS | ~42k | - | - | - | 18+ |
| Volume of 24h urine sample in milliliters | ur24h_volume_all_m_1 | U24HVOL | ~148k | ~103k | ~79k | 100+ | 18+ |
| Are any urinations for the 24h urine sample missed? | ur24h_missed_all_m_1 | PLGEM | ~148k | ~103k | ~79k | 100+ | 18+ |
| Creatinine in 24-hrs urine (mmol/L) | ur24hcreatinine_result_all_m_1 | UKR24 | ~148k | ~103k | ~79k | 100+ | 18+ |
| Albumin in 24h urine (mg/L) | ur24halbumin_result_all_m_1 | BABU24 | ~59k | ~0,2k | - | 100+ | 18+ |
| Albumin in 24h urine (mg/L) | ur24halbumin_result_all_m_2 | PABU24 | - | ~1,6k | - | - | 18+ |
| Magnesium in 24h urine (mg/L) | ur24hmagnesium_result_all_m_1 | MG24 | - | ~2,3k | - | - | 18+ |
| the early morning spot urine sample obtained within 24h (before or after) the blood sample | urems_blood_all_m_1 | EMS_BL | ~42k | - | - | - | 18+ |
| was the early morning spot urine sample obtained within 24h (before or after) the 24h urine sample? | urems_u24h_all_m_1 | EMS_24H | ~42k | - | - | - | 18+ |
| Creatinine in early morning spot urine (mmol/L) | uremscreatinine_result_all_m_1 | UKREMS | ~55k | - | - | - | 18+ |
| Albumin in early morning spot urine (mg/L) | uremsalbumin_result_all_m_1 | BABUEMS | ~55k | - | - | - | 18+ |
| the to urine sample obtained within 24h (before or after) the blood sample | urto_blood_all_m_1 | TO_BL | ~7.5k | ~5.2k | ~1.6k | - | 8 – 17 |
| Are any urinations for the timed-overnight urine sample missed? | urto_missed_all_m_1 | TOPLGEM | ~8.6k | ~6.2k | ~1.8k | - | 8 – 17 |
| Volume of timed-overnight urine sample in milliliters | urto_volume_all_m_1 | TOVOL | ~8.6k | ~6.2k | ~1.8k | - | 8 – 17 |
| Creatinine in timed-overnight urine (mmol/L) | urtocreatinine_result_all_m_1 | UKRTO | ~8.6k | ~6.2k | ~1.8k | - | 8 – 17 |
| Albumin in timed-overnight urine (mg/L) | urtoalbumin_result_all_m_1 | BABUTO | ~0,8k | - | - | - | 8 – 17 |
| Sodium in 24h urine (mg/L) | NAUR24 | - | - | - | 100+ | 18+ | |
| Potassium in 24h urine (mg/L) | KAUR24 | - | - | - | 100+ | 18+ | |
| Chloride in 24h urine (mg/L) | CLUR24 | - | - | - | 100+ | 18+ |
Additional assessment SALT
In the context of the additional assessment on salt intake, the following urine analyses have been performed.
| Label English | Label Dutch | Code | Variable | Assessment | Age |
| chloride in 24h urine (mmol/l) | chloride in 24-uurs urine (mmol/l) | ur24hchloride_result_all_m_1 | cl24 | SALT | 18+ |
| potassium in 24h urine (mmol/l) | kalium in 24-uurs urine (mmol/l) | ur24hpotassium_result_all_m_1 | k24 | SALT | 18+ |
| sodium in 24h urine (mmol/l) | natrium in 24-uurs urine (mmol/l) | ur24hsodium_result_all_m_1 | na24 | SALT | 18+ |
