Researchers from the University Medical Center Groningen performed a validation of the Pulmonary Function Test from participants at 1A visit 1 and 2A visit 1. Additionally, reference values have been developed. (sections: physical state (Pulmonary Function Test) and secondary & linked variables).
The spirometry variables can be requested in the Lifelines catalogue or by mail (data@lifelines.nl).
Spirometry is performed according to Standard Operating Procedures using the Welch Allyn SpiroPerfect device. Judgment on technical correctness is performed by a Lifelines assistant, a pulmonologist, or both, according to a standard review procedure. Only data from pulmonary function tests that are judged to be technically correct should be used in the analyses. Technically correct is defined as:
In case both the pulmonologist and the Lifelines assistant judged the technical correctness, the priority is given to the judgment of the pulmonologist.
Important: part of the spirometry results have been listed as technically invalid, as a result the researchers from the UMCG recommend you to NOT use these results in analyses.
To select only technically valid measurements the following rules were applied:
IF… | THEN… |
Review specialist is “ATS” (1) or “Not ATS, clinically reliable” (2) | Spirometry is technically correct |
Review specialist is “Not ATS, not to assess” (3) | Spirometry is not technically correct |
Review specialist is missing or “No announcement” (0) and Review assistant is “ATS” (1) or “Not ATS, clinically reliable” (2) | Spirometry is technically correct |
Review specialist is missing or “No announcement” (0) and Review assistant is “Not ATS, not to assess” (3) | Spirometry is not technically correct |
Other case | Spirometry is not technically correct |
Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the GLI provided syntax codes and databases.
Label English | Label Dutch | Code | Variable | Assessment | Age |
Technically valid spirometry? | Technisch correcte spirometrie? | spirometry_valid_all_c_1 | spiro_ok | 1A 2A | 18+ |
predicted FEV1 value (liter) | voorspelde FEV1 waarde (liter) | fev1_predicted_all_c_1 | FEV1_predicted | 1A 2A | 18+ |
predicted FEV1FVC value (liter) | voorspelde FEV1FVC waarde (liter) | fev1fvc_predicted_all_c_1 | FEV1FVC_predicted | 1A 2A | 18+ |
predicted FVC value (liter) | voorspelde FVC waarde (liter) | fcv_predicted_all_c_1 | FVC_predicted | 1A 2A | 18+ |
predicted FEF75 value (liter per second) | voorspelde FEF75 waarde (liter per seconde) | fef75_predicted_all_c_1 | FEF75_predicted | 1A 2A | 18+ |
predicted FEF25_75 (liter per second) | voorspelde FEF25_75 waarde (liter per seconde) | fef2575_predicted_all_c_1 | FEF2575_predicted | 1A 2A | 18+ |
z-score FEV1 value | z-score FEV1 waarde | fev1_zscore_all_c_1 | FEV1_zscore | 1A 2A | 18+ |
z-score FEV1FVC value | z-score FEV1FVC waarde | fev1fvc_zscore_all_c_1 | FEV1FVC_zscore | 1A 2A | 18+ |
z-score FVC value | z-score FVC waarde | fcv_zscore_all_c_1 | FVC_zscore | 1A 2A | 18+ |
z-score FEF75 value | z-score FEF75 waarde | fef75_zscore_all_c_1 | FEF75_zscore | 1A 2A | 18+ |
z-score FEF25_75 value | z-score FEF25_75 waarde | fef2575_zscore_all_c_1 | FEF2575_zscore | 1A 2A | 18+ |
Lower limit of normal FEV1 (liter) | Ondergrens van normale FEV1 (liter) | fev1_lowerlimit_all_c_1 | FEV1_LLN | 1A 2A | 18+ |
Lower limit of normal FEV1FVC (liter) | Ondergrens van normale FEV1FVC (liter) | fev1fvc_lowerlimit_all_c_1 | FEV1FVC_LLN | 1A 2A | 18+ |
Upper limit of normal FEV1FVC (liter) | Bovengrens van normale FEV1FVC (liter) | fev1fvc_upperlimit_all_c_1 | FEV1FVC_ULN | 1A 2A | 18+ |
Lower limit of normal FVC (liter) | Ondergrens van normale FVC (liter) | fvc_lowerlimit_all_c_1 | FVC_LLN | 1A 2A | 18+ |
Lower limit of normal FEF75 (liter per second) | Ondergrens van normale FEF75 (liter per seconde) | fef75_lowerlimit_all_c_1 | FEF75_LLN | 1A 2A | 18+ |
Lower limit of normal FEF25_75 (liter per second) | Ondergrens van normale FEF25_75 (liter per seconde) | fef2575_lowerlimit_all_c_1 | FEF2575_LLN | 1A 2A | 18+ |
FEV1 % predicted | FEV1 % voorspeld | fev1_percpredicted_all_c_1 | fev1pp | 1A 2A | 18+ |
FEV1FVC % predicted | FEV1FVC % voorspeld | fev1fvc_percpredicted_all_c_1 | fev1fvcpp | 1A 2A | 18+ |
FVC % predicted | FVC % voorspeld | fvc_percpredicted_all_c_1 | fvcpp | 1A 2A | 18+ |
FEF75 % predicted | FEF75 % voorspeld | fef75_percpredicted_all_c_1 | fef75pp | 1A 2A | 18+ |
FEF25_75 % predicted | FEF25_75 % voorspeld | fef2575_percpredicted_all_c_1 | fef2575pp | 1A 2A | 18+ |
change in FEV1 2A versus 1A (liter per year) | verandering in FEV1 2A versus 1A (liter per jaar) | fev1_change_all_c_1 | dfev1 | 2A | 18+ |
change in FEV1FVC 2A versus 1A (liter per year) | verandering in FEV1FVC 2A versus 1A (liter per jaar) | fev1fvc_change_all_c_1 | dfev1fvc | 2A | 18+ |
change in FVC 2A versus 1A (liter per year) | verandering in FVC1 2A versus 1A (liter per jaar) | fvc_change_all_c_1 | dfvc | 2A | 18+ |
change in FEF75 2A versus 1A (liter per second per year) | verandering in FEF75 2A versus 1A (liter per seconde per jaar) | fef75_change_all_c_1 | dfef75 | 2A | 18+ |
change in FEF25_75 2A versus 1A (liter per second per year) | verandering in FEF25_75 2A versus 1A (liter per seconde per jaar) | fef2575_change_all_c_1 | dfef2575 | 2A | 18+ |
difference in body length adults 2A versus 1A | verschil in lichaamslengte volwassenen 2A versus 1A | spirometry_bodylength_all_c_1 | heightdifference_adults | 2A | 18+ |