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Scalp Hair

Scalp hair samples were collected from ~59,000 adult Lifelines participants during 2A Visit 2. The main aim of hair collection was to use the samples for the assessment of hormone levels, e.g. cortisol (section: physical state).
The hair collection protocol was piloted in a subcohort of 300 participants in september 2013 (during 1A Visit 2) as an additional assessment initiated by researchers at the Department of Internal Medicine of Erasmus University, the Netherlands. During 2A visit 2 it was extended to ~59.000 participants. ~6000 samples have been analyzed for cortisol and cortisone and this data can be requested by sending an e-mail to data@lifelines.nl.

Background

Cortisol levels are typically assessed in serum, saliva, or urine samples. However, due to the circadian rhythm of cortisol, its pulsatile secretion, and the daily variation due to changing circumstances like acute stress, these samples provide non-representative snapshots of chronic cortisol levels in the human body. For that reason, a novel non-invasive parameter to measure cortisol using scalp hair was developed1), providing the unique opportunity to measure long-term cortisol levels that reflect the mean levels of several months (since hair grows with an average of 1 cm per month). Using this technique, it is now possible to study chronic cortisol levels over time in very large cohorts2).

Protocol

During 2A visit 2, participants were asked to provide a lock of hair. Nurse practitioners that assisted in the visit cut off a lock of hair close to the scalp using clean scissors. The lock of hair was placed in an envelope, clearly marked and registered, and stored at room temperature.
Participants also filled in a questionnaire about their hair, see the list of questions below.

Publications using Lifelines hair samples

Questionnaire

Participants provided the following information about their hair via a questionnaire:

Questions English Questions Dutch Code Variable Assessment Age
what is your natural hair colour at the moment? wat is op dit moment uw natuurlijke haarkleur? hair_colour_adu_q_1 hair1 2A 18+
how often do you wash your hair a week? hoe vaak wast u uw haren per week? hair_wash_adu_q_1 hair2 2A 18+
do you regularly perspire very heavily on your head, for instance when you are playing sports, in the sauna or for some other reason? transpireert u regelmatig zeer hevig op het hoofd, bijvoorbeeld tijdens het sporten, tijdens een bezoek aan de sauna of vanwege een andere reden? hair_perspiration_adu_q_1 hair3 2A 18+
average number of days a month of severe perspiration of the head gemiddeld aantal dagen per maand zeer hevig transpireren op het hoofd hair_perspiration_adu_q_1_a hair3a 2A 18+
have you used some form of corticosteroids (eg prednisone tablets, nasal spray, puffs, infusion, injection or skin creams) in the past three months? hebt u in de afgelopen 3 maanden een vorm van corticosteroïden (bv prednisontabletten, neusspray, longpufjes, infuus, injectie of huidcremès) gebruikt? hair_cortcosteroids_adu_q_1 hair4 2A 18+
tablets or capsules / how were the corticosteroids administered? tabletten of capsules / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_a hair4a1 2A 18+
infusion / how were the corticosteroids administered? infuus / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_b hair4a2 2A 18+
injection into joint, e.g. wrist, shoulder or knee / how were the corticosteroids administered? injectie in een gewricht, bv in pols, schouder of knie / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_c hair4a3 2A 18+
puffs (inhalation medication) / how were the corticosteroids administered? pufjes (inhalatiemedicatie) / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_d hair4a4 2A 18+
nasal spray / how were the corticosteroids administered? neusspray / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_e hair4a5 2A 18+
cream or ointment / how were the corticosteroids administered? crème of zalf / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_f hair4a6 2A 18+
if cream or ointment; where? / how were the corticosteroids administered? indien crème of zalf: waar? / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_f1 hair4a6a 2A 18+
other: / how were the corticosteroids administered? anders, nl / hoe werden de corticosteroïden toegediend? hair_cortcosteroids_adu_q_1_g hair4a7 2A 18+
has your hair been dyed, coloured, bleached or permanent-waved or did you have highlights or lowlights during the past six months? is uw haar geverfd, gekleurd, geblondeerd of gepermanent in de laatste 6 maanden of heeft u in deze periode highlights, lowlights of coupe soleil laten zetten? hair_treatment_adu_q_1 HAIR5 2A 18+
bleaching / what treatment did your hair have in the past six months? blonderen / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_a HAIR5A 2A 18+
when did you last bleach your hair? / what treatment did your hair have in the past six months? wanneer heeft u voor het laatst uw haar geblondeerd? / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_a1 HAIR5A1 2A 18+
highlights, lowlights or coupe soleil / what treatment did your hair have in the past six months? highlights, lowlights of coupe soleil / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_b HAIR5B 2A 18+
when did you last have highlights or lowlights? / what treatment did your hair have in the past six months? wanneer heeft u voor het laatst highlights, lowlights of coupe soleil laten zetten? / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_b1 HAIR5B1 2A 18+
colouring with permanent dye / what treatment did your hair have in the past six months? verven met permanente verf / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_c HAIR5C 2A 18+
when did you last colour your hair using permanent dye? / what treatment did your hair have in the past six months? wanneer heeft u voor het laatst uw haar geverfd met permanente verf? / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_c1 HAIR5C1 2A 18+
colouring with semi-permanent dye / what treatment did your hair have in the past six months? kleuren met kleurspoeling / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_d HAIR5D 2A 18+
when did you last colour your hair using semi-permanent dye? / what treatment did your hair have in the past six months? wanneer heeft u voor het laatst uw haar geverfd met kleurspoeling? / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_d1 HAIR5D1 2A 18+
permanent wave / what treatment did your hair have in the past six months? permanenten / welke behandeling heeft uw haar gehad in de laatste 6 maanden? hair_treatment_adu_q_1_e HAIR5E 2A 18+
when did yo last have a permanent wave? / what treatment did your hair have in the past six months? wanneer heeft u voor het laatst uw haar gepermanent? hair_treatment_adu_q_1_e1 HAIR5E1 2A 18+
Hebt u sinds de laatste keer dat u uw haar hebt gewassen een haarproduct gebruikt? HAIR6 Pilot 18+
Welk haarproduct hebt u gebruikt?: Mousse HAIR6A Pilot 18+
Welk haarproduct hebt u gebruikt?: Gel HAIR6B Pilot 18+
Welk haarproduct hebt u gebruikt?: Wax HAIR6C Pilot 18+
Welk haarproduct hebt u gebruikt?: Haarlak HAIR6D Pilot 18+
Welk haarproduct hebt u gebruikt?: Anders, nl. HAIR6E Pilot 18+
1)
Manenschijn L et al. (2011). Evaluation of a method to measure long term cortisol levels. Steroids 76(10-11):1032-1036
2)
Russell E. et al (2015). Toward standardization of hair cortisol measurement: results of the first international interlaboratory round robin. Therapeutic Drug Monitoring 37(1):71-75
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hair.txt · Last modified: 2024/04/29 11:11 by simone

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