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Urine Sample Analyses
The following variables were assessed in fresh urine samples collected from Lifelines participants during 1A Visit 2 and 2A Visit 2 (section: physical state).
Assessments were performed at the laboratory center of the University Medical Center Groningen that is certified according to NEN-EN-ISO 9001:2008 and NEN-EN-ISO 15189:2012 standards.
For more information about individual assays, see here.
Note that additional analyses were performed on blood samples collected on the same day.
Assessments
Creatinine in the urine together with urine flow rate and creatinine levels in the blood can be used to calculate the creatinine clearance rate; the measurement is performed using a Roche Enzymatic assay with a detection limit of 1.1 – 516 mg/dL (predilution factor 20), traceable to reference isotope dilution mass spectroscopy.
Albumin was determined using Tinaquant turbidimetric assay (Roche) to determine Proteinuria – a marker suggestive of illness e.g. kidney injury.
| English | Dutch | Code | Variable | Assessment | Age |
| was the 24h urine sample obtained within 24h (before or after) the blood sample? | was het 24-uurs urinemonster binnen 24h (voor of na) het bloedmonster genomen? | ur24h_blood_all_m_1 | 24H_BL | 1A 2A | 18+ |
| Are any urinations for the 24h urine sample missed? | Zijn er voor het 24-uurs urinemonster plassen gemist? | ur24h_missed_all_m_1 | PLGEM | 1A 2A | 18+ |
| was the 24h urine sample obtained within 24h (before or after) the early morning spot urine sample? | was het 24-uurs urinemonster binnen 24h (voor of na) het early morning spot urinemonster genomen? | ur24h_uems_all_m_1 | 24H_EMS | 1A 2A | 18+ |
| Volume of 24h urine sample in milliliters | Volume van 24-uurs urinemonster in milliliters | ur24h_volume_all_m_1 | U24HVOL | 1A | 18+ |
| Albumin in 24h urine (mg/L) | Albumine in 24-uurs urine (mg/L) | ur24halbumin_result_all_m_1 | BABU24 | 1A | 18+ |
| Albumin in 24h urine (mg/L) | Albumine in 24-uurs urine (mg/L) | ur24halbumin_result_all_m_2 | PABU24 | 1A | 18+ |
| Creatinine in 24-hrs urine (mmol/L) | Kreatinine in 24-uurs urine (mmol/L) | ur24hcreatinine_result_all_m_1 | UKR24 | 1A | 18+ |
| Magnesium in 24h urine (mg/L) | Magnesium in 24-uurs urine (mg/L) | ur24hmagnesium_result_all_m_1 | MG24 | 1A 2A | 18+ |
| was the early morning spot urine sample obtained within 24h (before or after) the blood sample? | was het early morning spot urinemonster binnen 24h (voor of na) het bloedmonster genomen? | urems_blood_all_m_1 | EMS_BL | 1A 2A | 8-17 |
| was the early morning spot urine sample obtained within 24h (before or after) the 24h urine sample? | was het early morning spot urinemonster binnen 24h (voor of na) het 24-uurs urinemonster genomen? | urems_u24h_all_m_1 | EMS_24H | 1A | 8-17 |
| Albumin in early morning spot urine (mg/L) | Albumine in early morning spot urine (mg/L) | uremsalbumin_result_all_m_1 | BABUEMS | 1A 2A | 8-17 |
| Creatinine in early morning spot urine (mmol/L) | Kreatinine in early morning spot urine (mmol/L) | uremscreatinine_result_all_m_1 | UKREMS | ||
| was the to urine sample obtained within 24h (before or after) the blood sample? | was het to urinemonster binnen 24h (voor of na) het bloedmonster genomen? | urto_blood_all_m_1 | TO_BL | ||
| Are any urinations for the 24h urine sample missed? | Zijn er voor het 24-uurs urinemonster plassen gemist? | urto_missed_all_m_1 | TOPLGEM | ||
| Volume of timed-overnight urine sample in milliliters | Volume van timed-overnight urinemonster in milliliters | urto_volume_all_m_1 | TOVOL | ||
| Albumin in timed-overnight urine (mg/L) | Albumine in timed-overnight urine (mg/L) | urtoalbumin_result_all_m_1 | BABUTO | ||
| Creatinine in timed-overnight urine (mmol/L) | Kreatinine in timed-overnight urine (mmol/L) | urtocreatinine_result_all_m_1 | UKRTO |
