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Table of Contents
Connective Tissue Disease (CSQ)
The Connective Tissue Disease Screening Questionnaire (CSQ) is a highly reproducible, sensitive, and moderately specific instrument for screening subjects with potential Connective Tissue Disease (CTD).
Note that musculoskeletal symptoms and diseases were also assessed in general within Lifelines (section: diseases & symptoms).
Background
Epidemiologic studies of the incidence of connective tissue diseases (CTDs) or their potential associations with exogenous risk factors are limited by the low prevalence, diverse manifestations, lack of specific diagnostic tests, and the expense associated with confirming the diagnosis. Screening by questionnaires such as the CTQ is a useful, validated, efficient case-finding strategy for systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ankylosing spondylitis.
The CSQ was developed in English and translated to Dutch. It has 30 items and can be completed within 30 minutes.
For all intended purposes a person who does not meet the CTD criteria by the CSQ, as described below, does not have a CTD. The instrument can be used to identify a smaller group for subsequent detailed, specific examination. It should prove useful in population studies of the incidence, prevalence, and etiology of CTDs1).
Diagnostic criteria
An algorithm for identifying potential CTD based on the ACR or published clinical criteria was used.
| CTD | Diagnostic criteria |
|---|---|
| Rheumatoid Arthritis (4 out of 6 criteria) | swelling of wrist, metacarpophalangeal, or proximal interphalangeal joints for more than 6 weeks |
| swelling of three or more joints for more than 6 weeks | |
| swelling of wrist, metacarpophalangeal, or proximal interphalangeal joints for more than 6 weeks | |
| symmetric joint swelling | |
| rheumatoid nodules | |
| positive test result for rheumatoid factor. | |
| X-ray findings were not ascertained. | |
| Lupus (SLE) (4 out of 11 criteria) | malar rash |
| discoid rash | |
| photosensitivity | |
| oral ulcers | |
| arthritis | |
| serositis | |
| proteinuria | |
| hematologic disorder (anemia, leukopenia, low platelet count) | |
| positive antinuclear antibody (ANA) titer | |
| alopecia and Raynaud’s phenomenon* | |
| seizures and psychosis were excluded* | |
| Scleroderma (1 major or 2> minor criteria) | major: skin thickening proximal to the metacarpophalangeal joints |
| minor: sclerodactyly, digital pitting scars or loss of substance from the finger pad | |
| minor: pulmonary fibrosis | |
| polymyositis or dermatomyositis (2 out of 4 criteria) | muscle weakness for more than 3 months |
| upper extremity proximal muscle weakness for more than 3 months | |
| lower extremity proximal muscle weakness for more than 3 months | |
| a history of an elevated muscle enzyme level (creatinine phosphokinase) | |
| electromyography and muscle biopsy results were not ascertained. | |
| Sjögren's syndrome (1 of 2 criteria) | dry eyes and dry mouth |
| positive serologic test results (ANA or rheumatoid factor) plus dry eyes or dry mouth | |
| lip biospy, Rose-bengal staining, and Schirmer’s test results were not ascertained. | |
| Raynaud’s phenomenon | cold sensitivity plus white, blue, or purple color changes of the fingers on exposure to cold |
| Mixed connective tissue disease (4 out of 5 criteria) | synovitis as defined by the RA algorithm (see above) |
| hand edema | |
| Raynaud’s phenomenon (see above) | |
| myositis as defined by the polymyositis/dermatomyositis algorithm (see above) | |
| acrosclerosis |
*Alopecia and Raynaud’s phenomenon were demonstrated by Tan and colleagues to have good sensitivity for SLE but lower specificity in distinguishing SLE from other CTDs. These were included because the goal of our study was to develop a highly sensitive instrument for detecting any CTD.
*Seizures and psychosis were not included because of their relatively low sensitivity (12 and
13%, respectively) in the study by Tan and colleagues.
Results of tests for immunologic disorders, anti-Smith (Sm) antibody, anti-double stranded DNA (dsDNA) antibody, and false positive serologic test for syphilis were not ascertained by questionnaire because we thought that most patients would not know the results of these laboratory tests.
Validation
See2)
Sensitivity and Specificity
Sensitivity of the CSQ (the proportion meeting CTD criteria on the CSQamong those with confirmed disease) ranged from 83% to 96% for individual CTDs. Specificity of the CSQ (the proportion not meeting CTD criteria among those without confirmed disease) ranged from 83 to 93%. Specificity for individual CTDs was better among general medical control subjects than among non-CTD control subjects. Specificity was lowest for polymyositis/dermatomyositis and Sjogren’s syndrome. Likelihood ratios (the
ability of the test to distinguish between diseased and nondiseased subjects) ranged from 5.0 for Sjogren’s syndrome to 11.9 for MCTD1.
Stratified Analysis of Specificity
Socioeconomic status was measured by educational level and health insurance status. We found significantly lower specificity among subjects with Medicaid or no health insurance and slightly lower specificity among less-educated subjects and those who were nonwhite. Specificity for detecting certain CTDs was significantly lower in patients with heart disease and depression.
Predictive Values
Positive predictive values in the study population, where the prevalence of CTD was much higher than in the general population, ranged from 23.5 to 84.9%. Positive predictive values in the general population, calculated assuming prevalence rates from population-based studies of CTD, ranged from 0.03% to 9.7%. As one would expect, the highest positive predictive value was for RA, the CTD with the highest prevalence in the general population. Negative predictive values were higher than 92% in the study population and higher than 99% in the general population.
Reliability
The K statistic calculated to evaluate test-retest reliability for detection of any potential CTD was 0.82, a rate indicating “excellent” reproducibility. Test-retest reliability values for specific CTDs were 0.50 for SLE, 0.80 for RA, 0.68 for scleroderma, 0.56 for polymyositis/dermatomyositis, 0.71 for Sjogren’s syndrome, and 0.68 for MCTD.
Variables
| Questions in English | Questions in Dutch | Variable | Assessment | Age |
| Have you had joint complaints for more than 3 months now? | Hebt u al langer dan 3 maanden gewrichtsklachten? | CSQ16 | 1C | 18+ |
| Have you ever had joint stiffness in the morning lasting at least 1 hour for more than 6 weeks? | Hebt u ooit langer dan 6 weken ’s ochtends minimaal 1 uur stijve gewrichten gehad? | CSQ17 | 1C | 18+ |
| Have you ever had nodules or bumps under the skin around your elbows or ankles? | Hebt u ooit knobbels of bulten onder de huid rond uw ellebogen of enkels gehad? | CSQ18 | 1C | 18+ |
| Have you ever had swelling in any of the following joints, lasting more than 6 weeks? | Zijn de volgende gewrichten ooit langer dan 6 weken gezwollen geweest? | |||
| Left wrist. | Pols (links) | CSQ19A1 | 1C | 18+ |
| Right wrist. | Pols (rechts) | CSQ19A2 | 1C | 18+ |
| Left finger joints (but not the joints nearest the fingernails). | Vingergewrichten (het gewricht het dichtst bij de nagel niet meetellen) (links) | CSQ19B1 | 1C | 18+ |
| Right finger joints (but not the joints nearest the fingernails). | Vingergewrichten (het gewricht het dichtst bij de nagel niet meetellen) (rechts) | CSQ19B2 | 1C | 18+ |
| Left elbow. | Elleboog (links) | CSQ19C1 | 1C | 18+ |
| Right elbow. | Elleboog (rechts) | CSQ19C2 | 1C | 18+ |
| Left knee. | Knie (links) | CSQ19D1 | 1C | 18+ |
| Right knee. | Knie (rechts) | CSQ19D2 | 1C | 18+ |
| Have you ever had a blood test for rheumatoid arthritis? | Is uw bloed ooit getest op reumatoïde artritis? | CSQ20/A | 1C | 18+ |
| Have you ever had a blood test for lupus/SLE? (e.g. ANA or ENA) | Is uw bloed ooit getest op lupus/ SLE ?(bijvoorbeeld ANA of ENA) | CSQ21/A | 1C | 18+ |
| Are your fingers unusually sensitive to the cold? | Zijn uw vingers overmatig gevoelig voor kou? | CSQ22 | 1C | 18+ |
| Have your fingers ever shown any unusual color changes in the cold? | Zijn uw vingers ooit abnormaal verkleurd geweest in de kou? Zo ja, was de kleur wit, blauw, paars, rood? | CSQ23A-D | 1C | 18+ |
| Have you ever had sores in your mouth or nose for more than 2 weeks at a time? | Hebt u ooit langer dan 2 weken zweertjes in uw mond of neus gehad? | CSQ24 | 1C | 18+ |
| Have you ever had a red rash on your cheeks for more than a month? | Hebt u ooit langer dan een maand rode uitslag op uw wangen gehad? | CSQ25 | 1C | 18+ |
| Have you ever had skin break out (rash) after being in the sun (not sunburn)? | Hebt u ooit huiduitslag (zonlichtallergie) gehad nadat u in de zon geweest bent (geen verbranding)? | CSQ26 | 1C | 18+ |
| Have you ever had pleurisy or chest pain made worse with deep breaths for more than a few days (not caused by a bruised rib or a cold)? | Hebt u ooit langer dan een paar dagen pijn gehad in uw longen, die erger werd bij diep inademen (niet veroorzaakt door een gekneusde rib of verkoudheid) | CSQ27 | 1C | 18+ |
| Have you ever had rapid loss of lots of hair? | Hebt u ooit veel haar verloren in korte tijd? | CSQ28 | 1C | 18+ |
| Have you ever had a seizure, convulsion, or fit? | Hebt u ooit een epileptische aanval gehad? | CSQ29 | 1C | 18+ |
| Have you ever had puffy, swollen fingers for more than a month? | Hebt u ooit langer dan een maand opgezette vingers gehad? | CSQ30 | 1C | 18+ |
| Have you ever had skin thickening or tightening of face, neck, trunk, arms or legs ? (Not caused by fluid retention.) | Is de huid van uw gezicht, nek romp, armen of benen ooit dikker of strakker dan normaal geweest ? (niet veroorzaakt door het vasthouden van vocht). | CSQ31 | 1C | 18+ |
| Have you ever had skin thickening or tightening of the fingers or toes? | Is de huid van uw vingers of tenen ooit dikker of strakker dan normaal geweest ? | CSQ32 | 1C | 18+ |
| Have you ever had sores leaving scars in the finger tips? | Hebt u ooit zweertjes op uw vingertoppen gehad die littekens achterlieten? | CSQ33 | 1C | 18+ |
| Have you ever had muscle weakness (less muscle strength than usual) for more than 3 months? | Hebt u ooit langer dan 3 maanden spierzwakte (minder spierkracht dan normaal) gehad? | CSQ34 | 1C | 18+ |
| Have you ever had difficulty rising from a chair for more than 3 months? | Hebt u ooit langer dan 3 maanden moeite gehad met het opstaan uit een stoel? | CSQ35 | 1C | 18+ |
| Have you ever had difficulty combing your hair for more than 3 months? | Hebt u ooit langer dan 3 maanden moeite gehad met het kammen van uw haar? | CSQ36 | 1C | 18+ |
| Have you ever had a gritty or sandy sensation in your eyes? | Hebt u ooit een korrelig of zanderig gevoel in uw ogen gehad? | CSQ37 | 1C | 18+ |
| Do you regularly wake up with a dry mouth, requiring you to drink water? | Wordt u regelmatig wakker door een droge mond waarvoor u water moet gaan drinken? | CSQ38 | 1C | 18+ |
| Have you ever been told by a doctor that you had | Heeft een dokter u ooit verteld dat u het volgende had: | |||
| anemia? | Bloedarmoede? | CSQ39A | 1C | 18+ |
| low white cell count? | Laag aantal witte bloedcellen? | CSQ39B | 1C | 18+ |
| low platelet count? | Laag aantal bloedplaatjes? | CSQ39C | 1C | 18+ |
| protein in your urine? | Eiwit in uw urine? | CSQ39D | 1C | 18+ |
| lupus/SLE of the skin? | Lupus/SLE van de huid? | CSQ39E | 1C | 18+ |
| scarring of the lungs (pulmonary fibrosis)? | Littekenweefsel in uw longen (longfibrose)? | CSQ39F | 1C | 18+ |
| Have you ever been told by a doctor that you had high CPK (muscle enzyme) in your blood? | Hoog CPK (spier-eiwit) in uw bloed? / Heeft een dokter u ooit verteld dat u het volgende had: | CSQ39G | 1C | 18+ |
