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| ====== Lifelines NEXT ====== | ====== Lifelines NEXT ====== | ||
| - | Lifelines NEXT is one of Lifelines' [[additional assessments]], performed in collaboration with the Department of Genetics at the [[https://www.umcg.nl/EN/corporate/Paginas/default.aspx|University Medical Center Groningen]]\\ | + | Lifelines NEXT is one of Lifelines' [[additional assessments]], performed in collaboration with the Department of Genetics at the [[https://www.umcg.nl/EN/corporate/Paginas/default.aspx|University Medical Center Groningen]].\\ |
| + | |||
| + | ===== Protocol ===== | ||
| - | PROTOCOL\\ | ||
| In [[https://www.lifelines.nl/deelnemers/onderzoek/next|Lifelines NEXT]] the aim is to primarily include 1500 pregnant women who participate in the regular Lifelines study. Secondary, participants can enroll who are not currently in the Lifelines cohort.\\ | In [[https://www.lifelines.nl/deelnemers/onderzoek/next|Lifelines NEXT]] the aim is to primarily include 1500 pregnant women who participate in the regular Lifelines study. Secondary, participants can enroll who are not currently in the Lifelines cohort.\\ | ||
| - | Participants are included from 12 weeks of gestation, mainly via midwives and obstetricians. They are closely followed, including their partners and children until at least one year after birth. Further long-term follow-up of physical and psychological health will be embedded following the [[cohort|Lifelines procedures]].\\ | + | Participants are included from 12 weeks of gestation, mainly via midwives and obstetricians. They are closely followed, including their partners and [[children]] until at least one year after birth. Further long-term follow-up of physical and psychological health will be embedded following the [[cohort|Lifelines procedures]].\\ |
| During the study period of Lifelines NEXT, biomaterials are collected including maternal and neonatal (cord) blood, placental tissue, feces breastmilk and urine at 10 different time points. Data on environmental factors, including continuous data collection from connected devices, social, medical and birth factors, including lifestyle related, reproduction related and nutritional factors are collected via questionnaires at 14 different time points.\\ | During the study period of Lifelines NEXT, biomaterials are collected including maternal and neonatal (cord) blood, placental tissue, feces breastmilk and urine at 10 different time points. Data on environmental factors, including continuous data collection from connected devices, social, medical and birth factors, including lifestyle related, reproduction related and nutritional factors are collected via questionnaires at 14 different time points.\\ | ||
| The extensive collection of different biomaterials during pregnancy and thereafter will give the opportunity to relate e.g. environmental factors and maternal and neonatal microbiome composition to epigenetic changes and health outcomes. The nesting of the study within Lifelines enables to include preconceptional transgenerational data, which largely extends familial information. | The extensive collection of different biomaterials during pregnancy and thereafter will give the opportunity to relate e.g. environmental factors and maternal and neonatal microbiome composition to epigenetic changes and health outcomes. The nesting of the study within Lifelines enables to include preconceptional transgenerational data, which largely extends familial information. | ||
| - | PERIOD\\ | + | ===== Period ===== |
| The first inclusion of Lifelines NEXT was October 2016. At the time of writing (July, 2019), the project consists of approx. 500 women, partners, and their (soon to be) newborns. | The first inclusion of Lifelines NEXT was October 2016. At the time of writing (July, 2019), the project consists of approx. 500 women, partners, and their (soon to be) newborns. | ||
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| {{ :next_questionnaires_overview_.pdf |Specific overview of questionnaire data collection}} | {{ :next_questionnaires_overview_.pdf |Specific overview of questionnaire data collection}} | ||
| - | + | ===== Publications using NEXT data ===== | |
| - | **Prepartum exposures** | + | * Warmink-Perdijk WDB et al. (2020) Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study. Eur J Epidemiol (in press) |
| - | + | ||
| - | | **Questions English** | **Questions Dutch** | **Variable** | **Assessment** | **Age** | | + | |
| - | | | Hebt u nu huisdieren in huis? | PET | [[NEXT]] | | | + | |
| - | | | Hebt u tijdens maand 1 tot en met 3 (de eerste drie maanden) van deze zwangerschap de volgende dieren in huis gehad? | | | | | + | |
| - | | | Kat(ten) | PET1 | [[NEXT]] | | | + | |
| - | | | Hond(en) | PET2 | [[NEXT]] | | | + | |
| - | | | Vogel(s) | PET3 | [[NEXT]] | | | + | |
| - | | | Konijn(en)/knaagdier(en) | PET4 | [[NEXT]] | | | + | |
| - | | | Ander(e) dier(en), nl. | PET5 | [[NEXT]] | | | + | |
| - | | | Hebt u tijdens maand 4 tot en met 6 (de middelste drie maanden) van deze zwangerschap huisdieren gehad? | PET6 | [[NEXT]] | | | + | |
| - | | | Hoeveel dieren had u, uitgesplitst per diersoort, tijdens maand 4 tot en met 6 (de middelste 3 maanden) van deze zwangerschap? (0, 1, 2, etc.) | | | | | + | |
| - | | | Aantal kat(ten) | PET7A | [[NEXT]] | | | + | |
| - | | | Aantal hond(en) | PET7B | [[NEXT]] | | | + | |
| - | | | Aantal vogel(s) | PET7C | [[NEXT]] | | | + | |
| - | | | Aantal konijn(en)/knaagdier(en)0, 1, 2, etc.) | PET7D | [[NEXT]] | | | + | |
| - | | | Aantal ander(e) dier(en):/ Hoeveel dieren had u, uitgesplitst per diersoort, tijdens maand 4 tot en met 6 (de middelste 3 maanden) van deze zwangerschap? (0, 1, 2, etc.) | PET7E | [[NEXT]] | | | + | |
| - | | | Kwamen tijdens maand 4 tot en met 6 (de middelste 3 maanden) van deze zwangerschap onderstaande dieren in uw woning? (Dit kunnen ook dieren van vrienden/familie zijn) | | | | | + | |
| - | | | Kat(ten) | PET8A | [[NEXT]] | | | + | |
| - | | | Hond(en)nden/familie zijn) | PET8B | [[NEXT]] | | | + | |
| - | | | Vogel(s)zijn) | PET8C | [[NEXT]] | | | + | |
| - | | | Konijn(en)/knaagdier(en)ook dieren van vrienden/familie zijn) | PET8D | [[NEXT]] | | | + | |
| - | | | Ander(e) dier(en)vrienden/familie zijn) | PET8E | [[NEXT]] | | | + | |
| - | | | Hebt u tijdens maand 7 tot en met 9 (de laatste drie maanden) van deze zwangerschap huisdieren gehad? | PET9 | [[NEXT]] | | | + | |
| - | | | Hoeveel dieren had u, uitgesplitst per diersoort, tijdens maand 7 tot en met 9 (de laatste 3 maanden) van deze zwangerschap? (0, 1, 2, etc.) | | | | | + | |
| - | | | Aantal kat(ten) | PET10A | [[NEXT]] | | | + | |
| - | | | Aantal hond(en) | PET10B | [[NEXT]] | | | + | |
| - | | | Aantal vogel(s) | PET10C | [[NEXT]] | | | + | |
| - | | | Aantal konijn(en)/knaagdier(en) | PET10D | [[NEXT]] | | | + | |
| - | | | Aantal ander(e) dier(en) | PET10E | [[NEXT]] | | | + | |
| - | | | Kwamen tijdens maand 7 tot en met 9 (de laatste 3 maanden) van deze zwangerschap onderstaande dieren in uw woning? (Dit kunnen ook dieren van vrienden/familie zijn) | | | | | + | |
| - | | | Kat(ten) | PET11A | [[NEXT]] | | | + | |
| - | | | Hond(en) | PET11B | [[NEXT]] | | | + | |
| - | | | Vogel(s) | PET11C | [[NEXT]] | | | + | |
| - | | | Konijn(en)/knaagdier(en)vrienden/familie zijn) | PET11D | [[NEXT]] | | | + | |
| - | | | Ander(e) dier(en)vrienden/familie zijn) | PET11E | [[NEXT]] | | | + | |
| - | | | Komt u weleens in contact met (radioactieve) straling? (Uitgezonderd straling van computer, televisie en mobiele telefoon) | WORKC2 | [[NEXT]] | | | + | |
| - | | | Komt de vader tijdens uw huidige zwangerschap in contact met (radioactieve) straling? (Uitgezonderd straling van computer, televisie en mobiele telefoon) | WORKC3 | [[NEXT]] | | | + | |
| - | | | Hebt u een baan met lichamelijk zwaar werk? (Bv. lang staan of veel lopen in bv. een fabriek, tuinbouw, landbouw of in de zorg) | WORKE2 | [[NEXT]] | | | + | |
| - | | | Ja, nl./ Hebt u een baan met lichamelijk zwaar werk? | WORKE2_1 | [[NEXT]] | | | + | |
| - | | | Hebt u tijdens uw zwangerschap met uw werk ook te maken met | | | | | + | |
| - | | | Ploegendienst, nachtdienst en/of onregelmatige werktijden | WORKE2_A | [[NEXT]] | | | + | |
| - | | | Extreme hitte of extreme kou | WORKE2_B | [[NEXT]] | | | + | |
| - | | | Lawaai | WORKE2_C | [[NEXT]] | | | + | |
| - | | | Lichaamstrillingen | WORKE2_D | [[NEXT]] | | | + | |
| - | | | Overdruk (hogere luchtdruk dan normaal, ook bij duiken) | WORKE2_E | [[NEXT]] | | | + | |
| - | | | Niets is van toepassing | WORKE2_F | [[NEXT]] | | | + | |
| - | | | Kwam u tijdens uw werk in contact met chemische stoffen? Zo ja, met welke? | WORKG/A | [[NEXT]] | | | + | |
| - | | | Oplosmiddelen (in verf, lak, lijm, reinigingsmiddelen en inkt) | WORKG1_A | [[NEXT]] | | | + | |
| - | | | Narcosegassen | WORKG2_B | [[NEXT]] | | | + | |
| - | | | Geneesmiddelen tegen kanker (cytostatica / chemotherapeutica) | WORKG3_C | [[NEXT]] | | | + | |
| - | | | Bestrijdingsmiddelen (bv. pesticiden) | WORKG4_D | [[NEXT]] | | | + | |
| - | | | Zware metalen of metaalverbindingen (bv. cadmium, kwik, lood, mangaan en chroom) | WORKG5_E | [[NEXT]] | | | + | |
| - | | | Anders, nl. | WORKG6_F | [[NEXT]] | | | + | |
| - | | | Oplosmiddelen (in verf, lak, lijm, reinigingsmiddelen en inkt) | WORKH1_A | [[NEXT]] | | | + | |
| - | | | Narcosegassen | WORKH2_B | [[NEXT]] | | | + | |
| - | | | Geneesmiddelen tegen kanker (cytostatica / chemotherapeutica) | WORKH3_C | [[NEXT]] | | | + | |
| - | | | Bestrijdingsmiddelen (bv. pesticiden) | WORKH4_D | [[NEXT]] | | | + | |
| - | | | Zware metalen of metaalverbindingen (bv. cadmium, kwik, lood, mangaan en chroom) | WORKH5_E | [[NEXT]] | | | + | |
| - | | | Anders, nl. | WORKH6_F | [[NEXT]] | | | + | |
| - | | | Komt u tijdens uw werk in contact met | | | | | + | |
| - | | | Zieke mensen | WORKJ1 | [[NEXT]] | | | + | |
| - | | | Gezelschapsdieren | WORKJ2 | [[NEXT]] | | | + | |
| - | | | Vee | WORKJ3 | [[NEXT]] | | | + | |
| - | | | Kleine kinderen | WORKJ4 | [[NEXT]] | | | + | |
| - | | | Natuur in bossen of plantsoenen | WORKJ5 | [[NEXT]] | | | + | |
| - | | | Rauw vlees | WORKJ6 | [[NEXT]] | | | + | |
| - | | | Afval(water) | WORKJ7 | [[NEXT]] | | | + | |
| - | | | Bloed, urine, speeksel of andere lichaamsvloeistoffen (ook via afval) | WORKJ8 | [[NEXT]] | | | + | |
| - | | | Ontlasting (poep, ook via afval) | WORKJ9 | [[NEXT]] | | | + | |
| - | | | Niets is van toepassing | WORKJ10 | [[NEXT]] | | | + | |
| - | + | ||
| - | + | ||
next.1567163283.txt.gz · Last modified: 2019/11/07 16:07 (external edit)
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