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====== Lifelines NEXT ====== | ====== Lifelines NEXT ====== | ||
- | Lifelines NEXT is one of Lifelines' | + | Lifelines NEXT is one of Lifelines' |
+ | |||
+ | ===== Protocol ===== | ||
- | PROTOCOL\\ | ||
In [[https:// | In [[https:// | ||
- | Participants are included from 12 weeks of gestation, mainly via midwives and obstetricians. They are closely followed, including their partners and children until at least one year after birth. Further long-term follow-up of physical and psychological health will be embedded following the [[cohort|Lifelines procedures]].\\ | + | Participants are included from 12 weeks of gestation, mainly via midwives and obstetricians. They are closely followed, including their partners and [[children]] until at least one year after birth. Further long-term follow-up of physical and psychological health will be embedded following the [[cohort|Lifelines procedures]].\\ |
During the study period of Lifelines NEXT, biomaterials are collected including maternal and neonatal (cord) blood, placental tissue, feces breastmilk and urine at 10 different time points. Data on environmental factors, including continuous data collection from connected devices, social, medical and birth factors, including lifestyle related, reproduction related and nutritional factors are collected via questionnaires at 14 different time points.\\ | During the study period of Lifelines NEXT, biomaterials are collected including maternal and neonatal (cord) blood, placental tissue, feces breastmilk and urine at 10 different time points. Data on environmental factors, including continuous data collection from connected devices, social, medical and birth factors, including lifestyle related, reproduction related and nutritional factors are collected via questionnaires at 14 different time points.\\ | ||
The extensive collection of different biomaterials during pregnancy and thereafter will give the opportunity to relate e.g. environmental factors and maternal and neonatal microbiome composition to epigenetic changes and health outcomes. The nesting of the study within Lifelines enables to include preconceptional transgenerational data, which largely extends familial information. | The extensive collection of different biomaterials during pregnancy and thereafter will give the opportunity to relate e.g. environmental factors and maternal and neonatal microbiome composition to epigenetic changes and health outcomes. The nesting of the study within Lifelines enables to include preconceptional transgenerational data, which largely extends familial information. | ||
- | PERIOD\\ | + | ===== Period ===== |
- | The first inclusion of Lifelines NEXT was October 2016. At the time of writing (July, 2019), the project consists of approx. | + | |
+ | The first inclusion of Lifelines NEXT was October 2016. Inclusion | ||
{{: | {{: | ||
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{{ : | {{ : | ||
- | | **Questions English** | + | ===== Publications using NEXT data ===== |
- | | How did the mother get pregnant? | + | |
- | | Specification other / How did the mother get pregnant? | + | |
- | | During months 1 - 3 (first trimester) of the pregnancy, did/was the mother | + | |
- | | use medication (including self-medication such as paracetamol etc.) | medicijnen gebruikt (ook zelfmedicatie zoals paracetamol e.d.)\\ \\ | CHPREG3 | + | |
- | | Name of medication (1-10) | Naam medicijn (1-10) | + | |
- | | Reason for medication (1-5) | Reden medicijn (1-5) | CHPREG3A-E2 | + | |
- | | How often did the mother take medication (1-5)? | + | |
- | | smoke | gerookt | + | |
- | | How many cigarettes a day did the mother smoke on average? | + | |
- | | exposed to other people' | + | |
- | | How much time per day in hours | Hoeveel tijd per dag in uren | CHPREG9A | + | |
- | | How much time per day in minutes | + | |
- | | drink alcohol | + | |
- | | How many glasses per week on average | + | |
- | | Were there any pets in the household while the mother was pregnant? | + | |
- | | have a cat | een kat in huis | CHPREG15B | + | |
- | | have a bird | een vogel in huis | CHPREG15D | + | |
- | | have a dog? | een hond in huis | CHPREG15A | + | |
- | | a guinea pig | een cavia in huis | CHPREG15C | + | |
- | | any other animal (1-2) | een ander dier (1-2) in huis? | CHPREG15E-F | + | |
- | | use medication (including self-medication such as paracetamol etc.) | medicijnen gebruikt (ook zelfmedicatie zoals paracetamol e.d.)\\ \\ | CHPREG3 | + | |
- | | smoke | gerookt | + | |
- | | During months 4 - 6 (second trimester) of the pregnancy, did the mother | + | |
- | | use medication (including self-medication such as paracetamol etc.) | medicijnen gebruikt (ook zelfmedicatie zoals paracetamol e.d.)\\ \\ | CHPREG4 | + | |
- | | Name of medication (1-10) | Naam medicijn (1-10) | + | |
- | | Reason for medication (1-5) | Reden medicijn (1-5) | CHPREG4A-E2 | + | |
- | | How often did the mother take medication (1-5)? | + | |
- | | smoke | gerookt | + | |
- | | How many cigarettes | + | |
- | | exposed | + | |
- | | How much time per day in hours | Hoeveel tijd per dag in uren | CHPREG10A | + | |
- | | How much time per day in minutes | + | |
- | | drink alcohol | + | |
- | | How many glasses per week on average | + | |
- | | have a cat | een kat in huis | CHPREG16A-F | + | |
- | | have a bird | een vogel in huis | CHPREG16B | + | |
- | | have a dog? | een hond in huis | CHPREG16C | + | |
- | | a guinea pig | een cavia in huis | CHPREG16D | + | |
- | | any other animal (1-2) | een ander dier (1-2) in huis? | CHPREG16E | + | |
- | | During months 7 - 9 (third trimester) of the pregnancy, did the mother | + | |
- | | use medication (including self-medication such as paracetamol etc.) | medicijnen gebruikt (ook zelfmedicatie zoals paracetamol e.d.)\\ \\ | CHPREG5 | + | |
- | | Name of medication | + | |
- | | Reason for medication (1-5) | Reden medicijn (1-5) | CHPREG5A-E2 | + | |
- | | How often did the mother take medication (1-5)? | + | |
- | | smoke | gerookt | + | |
- | | How many cigarettes a day did the mother smoke on average? | + | |
- | | exposed to other people' | + | |
- | | How much time per day in hours | Hoeveel tijd per dag in uren | CHPREG11A | + | |
- | | How much time per day in minutes | + | |
- | | drink alcohol | + | |
- | | How many glasses per week on average | + | |
- | | have a cat | een kat in huis | CHPREG17A | + | |
- | | have a bird | een vogel in huis | CHPREG17B | + | |
- | | have a dog? | een hond in huis | CHPREG17C | + | |
- | | a guinea pig | een cavia in huis | CHPREG17D | + | |
- | | any other animal (1-2) | een ander dier (1-2) in huis? | CHPREG17E-F | + | |
- | | What type of work did the mother do during the pregnancy? | + | |
- | | Specification job/ | + | |
- | | Specification number of hours | Specificatie aantal uren per week | CHPREG18A | + | |
- | | I don't know / don't remember | + | |
- | | For how many months of the pregnancy did the mother work? | Gedurende hoeveel maanden van de zwangerschap heeft de moeder gewerkt? | + | |
- | | I don't know / don't remember | + | |
- | | Did the mother work during the pregnancy? | + | |
- | | Specification postcode | + | |
- | | I don't remember / Where did the mother live during the pregnancy? | + | |
- | | How can you best describe the environment where the mother lived for most of her pregnancy? | + | |
- | | Specification other address / How can you best describe the environment where the mother lived for most of her pregnancy? | + | |
- | | Is there any information regarding the pregnancy, birth or the period after that which you have not mentioned yet but that you believe may be important for your child' | + | |
- | | Specification other important information / Is there any information regarding the pregnancy, birth or period after that which you have not mentioned yet but that you believe may be important for your child' | + | |
- | | Did the mother | + | |
- | | Did the mother take tablets with folic acid only or did she take a multivitamin with folic acid? | Heeft de moeder tabletten met alleen foliumzuur of een multivitamine met foliumzuur gebruikt? | + | |
- | | None of these / During what period of the pregnancy did the mother take folic acid? | Geen van onderstaande / In welke periode van uw zwangerschap heeft de moeder foliumzuur gebruikt? | + | |
- | | Started before the pregnancy but stopped / During what period of the pregnancy did the mother take folic acid? | Voor de zwangerschap begonnen maar ook weer gestopt / In welke periode van uw zwangerschap heeft de moeder foliumzuur gebruikt? | + | |
- | | Started before the pregnancy but stopped | + | |
- | | Started before the pregnancy and continued taking it during | + | |
- | | Started before the pregnancy and continued using in the first trimester (months 1-3) | Voor de zwangerschap begonnen en doorgebruikt in de eerste 3 maanden (maand 1-3) | CHPREG25B1 | + | |
- | | During the first trimester (months 1-3), after I found out I was pregnant / During what period of the pregnancy did the mother take folic acid? | In de eerste 3 maanden (maand 1-3), nadat ik wist dat ik zwanger was / In welke periode van uw zwangerschap heeft de moeder foliumzuur gebruikt? | + | |
- | | Started in the first trimester (months 1-3), after the mother knew she was pregnant | + | |
- | | Second trimester (months 4-6) / During what period of the pregnancy did the mother take folic acid? | Middelste 3 maanden (maand 4-6) / In welke periode van uw zwangerschap heeft de moeder foliumzuur gebruikt? | + | |
- | | Second trimester of the pregnancy (months 4-6) | Middelste 3 maanden van de zwangerschap (maand 4-6) | CHPREG25D1 | + | |
- | | Last trimester (months 7-9) / During what period of the pregnancy did the mother take folic acid? | Laatste 3 maanden (maand 7-9) / In welke periode van uw zwangerschap heeft de moeder foliumzuur gebruikt? | + | |
- | | Last trimester of the pregnancy (months 7-9) | Laatste 3 maanden van de zwangerschap (maand 7-9) | CHPREG25E1 | + | |
- | | I don't know / don't remember / During what period of the pregnancy did the mother take folic acid? | Weet ik niet (meer) / In welke periode van uw zwangerschap heeft de moeder foliumzuur gebruikt? | + | |
- | | Do you know during which period of the pregnancy the mother used folic acid? | Weet u gedurende welke periode van de zwangerschap de moeder foliumzuur heeft gebruikt? | + | |
- | | Did the mother take a higher dose (4 mg instead of 0.4 mg) on advice of the GP, obstetrician or gynaecologist? | + | |
- | | Specification reason for higher dose of folic acid / Did the mother take a higher dose (4 mg instead of 0.4 mg) on advice of the GP, obstetrician or gynaecologist? | + | |
- | | Specification other dose / Did the mother take a higher dose (4 mg instead of 0.4 mg) on advice of the GP, obstetrician or gynaecologist? | + | |
- | | Physical complaints of the mother not related to the pregnancy / For which complaints did the mother have to be hospitalised? | + | |
- | | I don't know / don't remember / For which complaints did the mother have to be hospitalised? | + | |
- | | Specification other physical complaints related to the pregnancy / For which complaints was the mother hospitalised? | + | |
- | | Specification potential health problems of the child / For which complaints did the mother have to be hospitalised? | + | |
- | | Specification physical complaints not related to the pregnancy / For which complaints was the mother hospitalised? | + | |
- | | | Hebt u nu huisdieren in huis? | PET | [[NEXT]] | + | |
- | | | Hebt u tijdens maand 1 tot en met 3 (de eerste drie maanden) van deze zwangerschap de volgende dieren in huis gehad? | + | |
- | | | Kat(ten) | + | |
- | | | Hond(en) | + | |
- | | | Vogel(s) | + | |
- | | | Konijn(en)/ | + | |
- | | | Ander(e) dier(en), nl. | PET5 | [[NEXT]] | + | |
- | | | Hebt u tijdens maand 4 tot en met 6 (de middelste drie maanden) van deze zwangerschap huisdieren gehad? | + | |
- | | | Hoeveel dieren had u, uitgesplitst per diersoort, tijdens maand 4 tot en met 6 (de middelste 3 maanden) van deze zwangerschap? | + | |
- | | | Aantal kat(ten) | + | |
- | | | Aantal hond(en) | + | |
- | | | Aantal vogel(s) | + | |
- | | | Aantal konijn(en)/ | + | |
- | | | Aantal ander(e) dier(en):/ Hoeveel dieren had u, uitgesplitst per diersoort, tijdens maand 4 tot en met 6 (de middelste 3 maanden) van deze zwangerschap? | + | |
- | | | Kwamen tijdens maand 4 tot en met 6 (de middelste 3 maanden) van deze zwangerschap onderstaande dieren in uw woning? (Dit kunnen ook dieren van vrienden/ | + | |
- | | | Kat(ten) | + | |
- | | | Hond(en)nden/ | + | |
- | | | Vogel(s)zijn) | + | |
- | | | Konijn(en)/ | + | |
- | | | Ander(e) dier(en)vrienden/ | + | |
- | | | Hebt u tijdens maand 7 tot en met 9 (de laatste drie maanden) van deze zwangerschap huisdieren gehad? | + | |
- | | | Hoeveel dieren had u, uitgesplitst per diersoort, tijdens maand 7 tot en met 9 (de laatste 3 maanden) van deze zwangerschap? | + | |
- | | | Aantal kat(ten) | + | |
- | | | Aantal hond(en) | + | |
- | | | Aantal vogel(s) | + | |
- | | | Aantal konijn(en)/ | + | |
- | | | Aantal ander(e) dier(en) | + | |
- | | | Kwamen tijdens maand 7 tot en met 9 (de laatste 3 maanden) van deze zwangerschap onderstaande dieren in uw woning? (Dit kunnen ook dieren van vrienden/ | + | |
- | | | Kat(ten) | + | |
- | | | Hond(en) | + | |
- | | | Vogel(s) | + | |
- | | | Konijn(en)/ | + | |
- | | | Ander(e) dier(en)vrienden/ | + | |
- | | | Kwam u tijdens uw laatste zwangerschap in contact met (radioactieve) straling? | + | |
- | | | Komt u weleens in contact met (radioactieve) straling? (Uitgezonderd straling van computer, televisie en mobiele telefoon) | + | |
- | | | Komt de vader tijdens uw huidige zwangerschap in contact met (radioactieve) straling? | + | |
- | | | Kwam de vader tijdens uw laatste zwangerschap in contact met (radioactieve) straling? | + | |
- | | | Had u tijdens uw laatste zwangerschap een baan met lichamelijk zwaar werk? (Lang staan of veel lopen in bv. een fabriek, tuinbouw, landbouw of in de zorg) | WORKE | [[QROA]] | + | |
- | | | Hebt u een baan met lichamelijk zwaar werk? (Bv. lang staan of veel lopen in bv. een fabriek, tuinbouw, landbouw of in de zorg) | WORKE2 | + | |
- | | | Ja, nl./ Hebt u een baan met lichamelijk zwaar werk? | WORKE2_1 | + | |
- | | | Hebt u tijdens uw zwangerschap met uw werk ook te maken met | + | |
- | | | Ploegendienst, | + | |
- | | | Extreme hitte of extreme kou | WORKE2_B | + | |
- | | | Lawaai | + | |
- | | | Lichaamstrillingen | + | |
- | | | Overdruk (hogere luchtdruk dan normaal, ook bij duiken) | + | |
- | | | Niets is van toepassing | + | |
- | | | Had u tijdens uw laatste zwangerschap een baan met lichamelijk zwaar werk? | | + | |
- | | | Ploegendienst, | + | |
- | | | Extreme hitte of extreme kou | WORKF2 | + | |
- | | | Lawaai | + | |
- | | | Lichaamstrillingen | + | |
- | | | Overdruk (hogere luchtdruk dan normaal, ook bij duiken) | + | |
- | | | Geen van bovenstaande | + | |
- | | | Kwam u tijdens uw werk in contact met chemische stoffen? Zo ja, met welke? | + | |
- | | | Oplosmiddelen (in verf, lak, lijm, reinigingsmiddelen en inkt) | WORKG1_A | + | |
- | | | Narcosegassen | + | |
- | | | Geneesmiddelen tegen kanker (cytostatica / chemotherapeutica) | + | |
- | | | Bestrijdingsmiddelen (bv. pesticiden) | + | |
- | | | Zware metalen of metaalverbindingen (bv. cadmium, kwik, lood, mangaan en chroom) | + | |
- | | | Anders, nl. | WORKG6_F | + | |
- | | | Met welke chemische stoffen kwam u tijdens uw werk tijdens uw laatste zwangerschap in contact? | + | |
- | | | Oplosmiddelen (in verf, lak, lijm, reinigingsmiddelen en inkt) | WORKG1 | + | |
- | | | Narcosegassen | + | |
- | | | Geneesmiddelen tegen kanker (cytostatica / chemotherapie) | + | |
- | | | Bestrijdingsmiddelen (bv. pesticiden) | + | |
- | | | Zware metalen of metaalverbindingen (bv. cadmium, kwik, lood, mangaan en chroom) | + | |
- | | | Anders, nl. | WORKG6 | + | |
- | | | Kwam de vader tijdens uw laatste zwangerschap in contact met chemische stoffen? | + | |
- | | | Oplosmiddelen (in verf, lak, lijm, reinigingsmiddelen en inkt) | WORKH1 | + | |
- | | | Narcosegassen | + | |
- | | | Geneesmiddelen tegen kanker (cytostatica / chemotherapie) | + | |
- | | | Bestrijdingsmiddelen (bv. pesticiden) | + | |
- | | | Zware metalen of metaalverbindingen (bv. cadmium, kwik, lood, mangaan en chroom) | + | |
- | | | Anders, nl. | WORKH6 | + | |
- | | | Komt de vader tijdens uw huidige zwangerschap in contact met chemische stoffen? | + | |
- | | | Oplosmiddelen (in verf, lak, lijm, reinigingsmiddelen en inkt) | WORKH1_A | + | |
- | | | Narcosegassen | + | |
- | | | Geneesmiddelen tegen kanker (cytostatica / chemotherapeutica) | + | |
- | | | Bestrijdingsmiddelen (bv. pesticiden) | + | |
- | | | Zware metalen of metaalverbindingen (bv. cadmium, kwik, lood, mangaan en chroom) | + | |
- | | | Anders, nl. | WORKH6_F | + | |
- | | | Kwam u tijdens uw werk tijdens uw laatste zwangerschap in contact met: | | + | |
- | | | Zieke mensen of dieren | + | |
- | | | Kleine kinderen/ Kwam u tijdens uw werk tijdens uw laatste zwangerschap in contact met: | WORKI2 | + | |
- | | | Natuur in bossen of plantsoenen | + | |
- | | | Rauw vlees | WORKI4 | + | |
- | | | Afval(water) | + | |
- | | | Bloed, urine, speeksel of andere lichaamsvloeistoffen (ook via afval) | + | |
- | | | Ontlasting (poep), ook via afval | WORKI7 | + | |
- | | | Geen van bovenstaande | + | |
- | | | Komt u tijdens uw werk in contact met | + | |
- | | | Zieke mensen | + | |
- | | | Gezelschapsdieren | + | |
- | | | Vee | WORKJ3 | + | |
- | | | Kleine kinderen | + | |
- | | | Natuur in bossen of plantsoenen | + | |
- | | | Rauw vlees | WORKJ6 | + | |
- | | | Afval(water) | + | |
- | | | Bloed, urine, speeksel of andere lichaamsvloeistoffen (ook via afval) | + | |
- | | | Ontlasting (poep, ook via afval) | + | |
- | | | Niets is van toepassing | + |
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