hair
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| - | ====== | + | ====== Hair ====== |
| - | Scalp hair samples were collected from ~59,000 adult [[start|Lifelines]] participants | + | [[start|Lifelines]] participants |
| - | The hair collection protocol was piloted in a subcohort | + | These questions can be combined with the analyses |
| - | ===== Background ===== | + | | **Questions English** |
| - | Cortisol levels are typically assessed in serum, saliva, or urine samples. However, due to the circadian rhythm of cortisol, its pulsatile secretion, and the daily variation due to changing circumstances like acute stress, these samples provide non-representative snapshots of chronic cortisol levels in the human body. | + | | what is your natural hair colour at the moment? |
| - | For that reason, a novel non-invasive parameter to measure cortisol using scalp hair was developed((Manenschijn L et al. (2011). Evaluation of a method to measure long term cortisol levels. Steroids 76(10-11): | + | | how often do you wash your hair a week? |
| - | + | | do you regularly perspire very heavily on your head, for instance when you are playing sports, in the sauna or for some other reason? | |
| - | ===== Protocol ===== | + | | average |
| - | During [[2A visit 2]], participants were asked to provide a lock of hair. Nurse practitioners that assisted in the visit cut off a lock of hair close to the scalp using clean scissors. The lock of hair was placed in an envelope, clearly marked and registered, and stored at room temperature.\\ | + | | have you used some form of corticosteroids (eg prednisone tablets, nasal spray, puffs, infusion, injection or skin creams) in the past three months? |
| - | Participants also filled in a questionnaire about their hair, see the list of questions below. | + | | tablets or capsules / how were the corticosteroids administered? |
| - | + | | infusion / how were the corticosteroids administered? | |
| - | ===== Publications using Lifelines hair samples ===== | + | | injection |
| - | * Wester et al. (2017) Hair analysis reveals subtle HPA axis suppression associated with use of local corticosteroids: | + | | puffs (inhalation medication) |
| - | * van Manen et al. (2019) Scalp hair cortisol and testosterone levels in patients with sarcoidosis. Plos ONE 14(6): e0215763 | + | | nasal spray / how were the corticosteroids administered? |
| - | * Savas et al. (2019) Hair glucocorticoids as biomarker for endogenous Cushing' | + | | cream or ointment |
| - | * Shukur et al. (2020) Hair cortisol-a method to detect chronic cortisol levels in patients with Prader-Willi syndrome. BMC Endocr Disord; 20(1):166 | + | | if cream or ointment; |
| - | + | | other: / how were the corticosteroids administered? | |
| - | ===== Questionnaire ===== | + | | has your hair been dyed, coloured, bleached or permanent-waved or did you have highlights or lowlights during the past six months? |
| - | Participants provided the following information about their hair via a questionnaire: | + | | bleaching |
| - | + | | when did you last bleach your hair? / what treatment did your hair have in the past six months? | |
| - | | **Questions English** | + | | highlights, lowlights |
| - | | What is your natural hair colour at the moment? | + | | when did you last have highlights or lowlights? |
| - | | How often do you wash your hair a week? | + | | colouring |
| - | | Do you regularly perspire very heavily on your head, for instance when you are playing sports, in the sauna or for some other reason? | + | | when did you last colour your hair using permanent dye? / what treatment did your hair have in the past six months? |
| - | | Average | + | | colouring |
| - | | Have you used some form of corticosteroids (e.g. prednisone tablets, nasal spray, puffs, infusion, injection or skin creams) in the past three months? | + | | when did you last colour your hair using semi-permanent dye? / what treatment did your hair have in the past six months? |
| - | | How were the corticosteroids administered? | + | | permanent |
| - | | Tablets or capsules | + | | when did yo last have a permanent wave? / what treatment did your hair have in the past six months? |
| - | | Infusion | + | | |
| - | | Injection | + | | |
| - | | Puffs (inhalation medication) | + | | |
| - | | Nasal spray | + | | |
| - | | Cream or ointment | + | | |
| - | | If cream or ointment; | + | | |
| - | | Other: | Anders, nl. / Hoe werden de corticosteroïden toegediend? | + | |
| - | | Has your hair been dyed, coloured, bleached or permanent-waved or did you have highlights or lowlights during the past six months? | + | |
| - | | Bleaching | + | |
| - | | When did you last bleach your hair? | + | |
| - | | Highlights, lowlights / What treatment did your hair have in the past six months? | + | |
| - | | When did you last have highlights or lowlights? | + | |
| - | | Colouring | + | |
| - | | When did you last colour your hair using permanent dye? | + | |
| - | | Colouring | + | |
| - | | When did you last colour your hair using semi-permanent dye? | Wanneer | + | |
| - | | Permanent | + | |
| - | | When did yo last have a permanent wave? | + | |
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