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--- urine_analyses [2020/10/09 11:14] – [Table] trynke
+++ urine_analyses [2025/02/05 13:49] (current) – external edit 127.0.0.1
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 ====== Urine Sample Analyses ======
-The following variables were assessed in fresh [[urine samples]] collected from [[start|Lifelines]] participants during [[1A Visit 2]] and [[2A Visit 2]] ([[sections|section]]: [[physical state]]).\\
+The following variables were assessed in fresh [[urine samples]] collected from [[start|Lifelines]] participants during [[1A Visit 2]], [[2A Visit 2]] and [[3A Visit 2]] ([[sections|section]]: [[physical state]]).\\
 Assessments were performed at the laboratory center of the [[https://www.umcg.nl|University Medical Center Groningen]] that is [[https://www.umcg.nl/NL/UMCG/Afdelingen/Laboratoriumgeneeskunde/Professionals/KwaliteitscertificatenAanvragen/Paginas/default.aspx|certified]] according to NEN-EN-ISO 9001:2008 and NEN-EN-ISO 15189:2012 standards.\\
 For more information about individual assays, see [[https://www.umcg.nl/NL/UMCG/Afdelingen/Laboratoriumgeneeskunde/Professionals/bepalingenwijzer/Paginas/bepalingenwijzer.aspx|here]].\\
-Note that additional analyses were performed on [[blood samples]] collected on the same day.
+Note that additional analyses were performed on [[blood analyses|blood]] samples collected on the same day.
 ===== Assessments =====
-**Creatinine** in the urine together with urine flow rate and creatinine levels in the blood can be used to calculate the creatinine clearance rate; the measurement is performed using a Roche Enzymatic assay with a detection limit of 1.1 – 516 mg/dL (predilution factor 20), traceable to reference isotope dilution mass spectroscopy.\\
+**Creatinine** in the urine together with urine flow rate and creatinine levels in the blood can be used to calculate the creatinine clearance rate; the measurement is performed using a Roche Enzymatic assay with a detection limit of 0,097 - 45 mmol/L (predilution factor 20), traceable to reference isotope dilution mass spectroscopy.\\
 **Albumin** was determined using Tinaquant turbidimetric assay (Roche) to determine Proteinuria – a marker suggestive of illness e.g. kidney injury.
-| **English**                                                                                          | **Code**                        | **Variable**  | N @ [[1A Visit 2|1A]]  | N @ [[2A Visit 2|2A]]  | **Age**  |
+| **English**                                                                                          | **Code**                        | **Variable**  | **N @ [[1A Visit 2|1A]]**  | **N @ [[2A Visit 2|2A]]**  | **N @ [[3A Visit 2|3A]]**  | **N @ 4A**  | **Age**  |
-| was the 24h urine sample obtained within 24h (before or after) the blood sample?                     | ur24h_blood_all_m_1             | 24H_BL        | ~148k                  | ~103k                  | 18+      |
+| the 24h urine sample was obtained within 24h (before or after) the blood sample                     | ur24h_blood_all_m_1             | 24H_BL        | ~131k | ~99k | ~78k | 100+ | 18+ |
-| was the 24h urine sample obtained within 24h (before or after) the early morning spot urine sample?  | ur24h_uems_all_m_1              | 24H_EMS       | ~148k                  | ~103k                  | 18+      |
+| the 24h urine sample was obtained within 24h (before or after) the early morning spot urine sample  | ur24h_uems_all_m_1              | 24H_EMS       | ~42k | - | - | - | 18+ |
-| Volume of 24h urine sample in milliliters                                                            | ur24h_volume_all_m_1            | U24HVOL       | ~148k                  | ~103k                  | 18+      |
+| Volume of 24h urine sample in milliliters                                                            | ur24h_volume_all_m_1            | U24HVOL       | ~148k | ~103k | ~79k | 100+ | 18+ |
-| Are any urinations for the 24h urine sample missed?                                                  | ur24h_missed_all_m_1            | PLGEM         | ~148k                  | ~103k                  | 18+      |
+| Are any urinations for the 24h urine sample missed?                                                  | ur24h_missed_all_m_1            | PLGEM         | ~148k | ~103k | ~79k | 100+ | 18+      |
-| Creatinine in 24-hrs urine (mmol/L)                                                                  | ur24hcreatinine_result_all_m_1  | UKR24         | ~148k                  | ~103k                  | 18+      |
+| Creatinine in 24-hrs urine (mmol/L)                                                                  | ur24hcreatinine_result_all_m_1  | UKR24         | ~148k | ~103k | ~79k | 100+ | 18+      |
-| Albumin in 24h urine (mg/L)                                                                          | ur24halbumin_result_all_m_1     | BABU24        | ~59k                   | ~0,2k                  | 18+      |
+| Albumin in 24h urine (mg/L)                                                                          | ur24halbumin_result_all_m_1     | BABU24        | ~59k | ~0,2k | - | 100+ | 18+      |
-| Albumin in 24h urine (mg/L)                                                                          | ur24halbumin_result_all_m_2     | PABU24        | -                      | ~1,6k                  | 18+      |
+| Albumin in 24h urine (mg/L)                                                                          | ur24halbumin_result_all_m_2     | PABU24        | - | ~1,6k | - | - | 18+      |
-| Magnesium in 24h urine (mg/L)                                                                        | ur24hmagnesium_result_all_m_1   | MG24          | -                      | ~2,3k                  | 18+      |
+| Magnesium in 24h urine (mg/L)                                                                        | ur24hmagnesium_result_all_m_1   | MG24          | - | ~2,3k | - | - | 18+      |
-| was the early morning spot urine sample obtained within 24h (before or after) the blood sample?      | urems_blood_all_m_1             | EMS_BL        | ~55k                   | -                      | 18+      |
+| the early morning spot urine sample obtained within 24h (before or after) the blood sample      | urems_blood_all_m_1             | EMS_BL        | ~42k | - | - | - | 18+      |
-| was the early morning spot urine sample obtained within 24h (before or after) the 24h urine sample?  | urems_u24h_all_m_1              | EMS_24H       | ~55k                   | -                      | 18+      |
+| was the early morning spot urine sample obtained within 24h (before or after) the 24h urine sample?  | urems_u24h_all_m_1              | EMS_24H       | ~42k| - | - | - | 18+ |
-| Creatinine in early morning spot urine (mmol/L)                                                      | uremscreatinine_result_all_m_1  | UKREMS        | ~55k                   | -                      | 18+      |
+| Creatinine in early morning spot urine (mmol/L)                                                      | uremscreatinine_result_all_m_1  | UKREMS        | ~55k | - | - | - | 18+ |
-| Albumin in early morning spot urine (mg/L)                                                           | uremsalbumin_result_all_m_1     | BABUEMS       | ~55k                   | -                      | 18+      |
+| Albumin in early morning spot urine (mg/L)                                                           | uremsalbumin_result_all_m_1     | BABUEMS       | ~55k | - | - | - | 18+ |
-| was the to urine sample obtained within 24h (before or after) the blood sample?                      | urto_blood_all_m_1              | TO_BL         | ~5k                    | ~6k                    | 8-17     |
+| the to urine sample obtained within 24h (before or after) the blood sample                      | urto_blood_all_m_1              | TO_BL         | ~7.5k | ~5.2k | ~1.6k | - | 8 – 17 |
-| Are any urinations for the timed-overnight urine sample missed?                                      | urto_missed_all_m_1             | TOPLGEM       | ~5k                    | ~6k                    | 8-17     |
+| Are any urinations for the timed-overnight urine sample missed?                                      | urto_missed_all_m_1             | TOPLGEM       | ~8.6k | ~6.2k | ~1.8k | - | 8 – 17 |
-| Volume of timed-overnight urine sample in milliliters                                                | urto_volume_all_m_1             | TOVOL         | ~5k                    | ~6k                    | 8-17     |
+| Volume of timed-overnight urine sample in milliliters                                                | urto_volume_all_m_1             | TOVOL         | ~8.6k | ~6.2k | ~1.8k | - | 8 – 17 |
-| Creatinine in timed-overnight urine (mmol/L)                                                         | urtocreatinine_result_all_m_1   | UKRTO         | ~5k                    | ~6k                    | 8-17     |
+| Creatinine in timed-overnight urine (mmol/L)                                                         | urtocreatinine_result_all_m_1   | UKRTO         | ~8.6k | ~6.2k | ~1.8k | - | 8 – 17 |
-| Albumin in timed-overnight urine (mg/L)                                                              | urtoalbumin_result_all_m_1      | BABUTO        | ~0,8k                  | -                      | 8-17     |
+| Albumin in timed-overnight urine (mg/L)                                                              | urtoalbumin_result_all_m_1      | BABUTO        | ~0,8k | - | - | - | 8 – 17 |
+| Sodium in 24h urine (mg/L) |  | NAUR24 | - | - | - | 100+ | 18+ |
+| Potassium in 24h urine (mg/L) |  | KAUR24 | - | - | - | 100+ | 18+ |
+| Chloride in 24h urine (mg/L) |  | CLUR24 | - | - | - | 100+ | 18+ |
+\\
+===Additional assessment SALT===
+In the context of the additional assessment on [[SALT|salt intake]], the following urine analyses have been performed.
+| **Label English**                | **Label Dutch**                     | **Code**                       | **Variable**  | **Assessment**  | **Age**  |
+| chloride in 24h urine (mmol/l)   | chloride in 24-uurs urine (mmol/l)  | ur24hchloride_result_all_m_1   | cl24          | [[SALT]]        | 18+      |
+| potassium in 24h urine (mmol/l)  | kalium in 24-uurs urine (mmol/l)    | ur24hpotassium_result_all_m_1  | k24           | [[SALT]]        | 18+      |
+| sodium in 24h urine (mmol/l)     | natrium in 24-uurs urine (mmol/l)   | ur24hsodium_result_all_m_1     | na24          | [[SALT]]        | 18+      |