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spirometry_validation [2021/05/06 17:50] laura |
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Researchers from the [[https://www.rug.nl/staff/j.m.vonk/|University Medical Center Groningen]] performed a validation of the [[Pulmonary Function Test]] from participants at [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]]. Additionally, reference values have been developed. ([[sections]]: [[physical state]] ([[Pulmonary Function Test]]) and [[secondary & linked variables]]).\\ | Researchers from the [[https://www.rug.nl/staff/j.m.vonk/|University Medical Center Groningen]] performed a validation of the [[Pulmonary Function Test]] from participants at [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]]. Additionally, reference values have been developed. ([[sections]]: [[physical state]] ([[Pulmonary Function Test]]) and [[secondary & linked variables]]).\\ | ||
- | The spirometry variables can be requested in the Lifelines catalogue or by mail (data@lifelines.nl).\\ | + | The spirometry variables can be requested in the [[https://data-catalogue.lifelines.nl/|Lifelines catalogue]].\\ |
===== Validation ===== | ===== Validation ===== | ||
- | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the WEllch Allyn SpiroPerfect device. Judgment on technical correctness is performed by a Lifelines assistant, a pulmonologist, or both, according to a standard review procedure. Only data from pulmonary function tests that are judged to be technically correct should be used in the analyses. Technically correct is defined as: | + | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the Welch Allyn SpiroPerfect device. Judgment on technical correctness is performed by a Lifelines assistant, a pulmonologist, or both, according to a standard review procedure. Only data from pulmonary function tests that are judged to be technically correct should be used in the analyses. Technically correct is defined as: |
* Test performed according to ATS criteria or | * Test performed according to ATS criteria or | ||
* Test not performed according to ATS criteria, but clinically reliable. | * Test not performed according to ATS criteria, but clinically reliable. | ||
In case both the pulmonologist and the Lifelines assistant judged the technical correctness, the priority is given to the judgment of the pulmonologist.\\ | In case both the pulmonologist and the Lifelines assistant judged the technical correctness, the priority is given to the judgment of the pulmonologist.\\ | ||
**Important:** part of the spirometry results have been listed as technically invalid, as a result the researchers from the UMCG recommend you to __NOT__ use these results in analyses.\\ | **Important:** part of the spirometry results have been listed as technically invalid, as a result the researchers from the UMCG recommend you to __NOT__ use these results in analyses.\\ | ||
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=== Validation rules === | === Validation rules === | ||
To select only technically valid measurements the following rules were applied: | To select only technically valid measurements the following rules were applied: | ||
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|Other case|Spirometry is not technically correct| | |Other case|Spirometry is not technically correct| | ||
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===== Reference values ===== | ===== Reference values ===== | ||
Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the [[https://www.ers-education.org/guidelines/global-lung-function-initiative.aspx|GLI provided syntax codes and databases]]. | Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the [[https://www.ers-education.org/guidelines/global-lung-function-initiative.aspx|GLI provided syntax codes and databases]]. | ||
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=== Remarks UMCG researcher === | === Remarks UMCG researcher === | ||
* It is important to note that ethnicity has not been taken into account. Everyone has been treated as Caucasian. | * It is important to note that ethnicity has not been taken into account. Everyone has been treated as Caucasian. | ||
- | * There are a few adults subjects with a huge difference in height between [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] resulting in a huge difference in reference values. It is recommended to exclude the adult subjects with a height difference of more than 5 cm using the height variable. | + | * There are a few adults subjects with a huge difference in height between [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] resulting in a huge difference in reference values. It is recommended to exclude the adult subjects with a height difference of more than 5 cm using the height variable.\\ |
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===== Article ===== | ===== Article ===== | ||
- | * Mahon, G. M., Koppelman, G. H., & Vonk, J. M. (2021). Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study. Thorax, 76(5), 441-447. DOI: 10.1136/thoraxjnl-2020-215232 | + | * Mahon, G. M., Koppelman, G. H., & Vonk, J. M. (2021). Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study. Thorax, 76(5), 441-447. DOI: 10.1136/thoraxjnl-2020-215232\\ |
===== Variables ===== | ===== Variables ===== |