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--- imal [2024/07/12 14:18] – trynke
+++ imal [2025/04/22 14:22] (current) – trynke
@@ Line 13: / Line 13: @@
   * vascular calcification
   * lung nodules
+Participants with a lung nodule between 100-300 mm3 (~5,4% of all scanned participants) were invited for a repeat CT scan after 3-4 months for scientific purposes, to evaluate natural evolution of lung nodules in the general population.
 ===== Subcohort =====
-Imalife ran from 2017 to 2022. The assessments were performed in ~12.000 Lifelines [[cohort|participants]] of ≥45 years who completed a [[pulmonary function test]].
+Imalife ran from 2017 to 2022. The assessments were performed in ~12.000 Lifelines [[cohort|participants]] of 45+ years who completed a [[pulmonary function test]].\\
+To ensure sufficient participants in the older age groups, selection criteria were later adjusted to 60+ and, in the final phase, 75+.
 ===== Publications using Imalife data =====
@@ Line 32: / Line 35: @@
   * Sourlos, N. et al. (2024) [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102890/|Effect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT]] Eur Radiol Exp 8(1):63
   * Dudurych I et al. (2024) [[https://pubs.rsna.org/doi/epdf/10.1148/radiol.232677|Low-dose CT–derived bronchial parameters in individuals with healthy lungs]] Radiology 311(3):e23267
+===== Spin-offs =====
+Imalife has resulted in 3 'spin-off' projects among the Imalife subcohort participants:
+  * Biolife
+  * Cardiolife ([[https://www.sciencedirect.com/science/article/pii/S0002870322000059?via%3Dihub|cohort paper]])
+  * Memolife