Differences

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--- cohort [2025/02/05 13:49] – external edit 127.0.0.1
+++ cohort [2026/09/23 09:53] (current) – trynke
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 ===== Family connections =====
-Lifelines includes many participants with a family connection to one another, including 355 twins and 5 triplets. Current and past family connections between participants are identified using:
+Lifelines includes many participants with a [[family_relations|family connection]] to one another, including 355 twins and 5 triplets. Current and past family connections between participants are identified using:
   * The [[https://www.government.nl/documents/leaflets/2017/01/19/brochure-brp-engelstalig|Dutch citizen registration]]
   * Self-reported information
   * Genotyping (see [[GWAS]] and [[UGLI]])
-Based on BRP and self-report, the following Lifelines [[https://en.wikipedia.org/wiki/Nuclear_family|nuclear families]] can be identified:
-| Number of families       |        ^ Child(ren) = LL Participant(s)                             |||||
-^ Parent = LL participant  | Total  | 1                               | 2      | 3     | 4    | 5    |
-| Only the mother          | ~2200  | ~1500                           | ~600   | ~80   | <10  | <10  |
-| Only the father          | ~350   | ~250                            | ~80    | ~10   | <10  | <10  |
-| Mother and father        | ~5000  | ~2600                           | ~2000  | ~350  | ~40  | <10  |
-Other family connections (e.g. grandparent-grandchild, siblings) are present in the cohort as well.
 ===== Cohort Facts & Representativity =====
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   * [[DAG3]] subcohort (9,500 participants with extensive metabolomics/microbiomics)
+{{ :omics.jpg?400 |}}
 ===== Data Linkage =====
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   * Individual data from **governmental registries** (i.e. causes of death, socio-economic data) can  be linked to Lifelines health-related data via [[http://www.cbs.nl/microdata|Statistics Netherlands]]
   * Individual results from **pathological tests** (i.e. biopsies) can be linked to Lifelines health-related data (including self-reported [[cancer]]) via [[https://www.palga.nl|PALGA]] and [[https://www.zorgttp.nl|ZorgTTP]]
-  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]] (the {{ ::pharmlines_procedures_20210415.pdf|Pharmlines}} initiative)
+  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]] (the {{ ::pharmlines_procedures_20210415.pdf|Pharmlines}} initiative). Data on prescription medication can be linked for approximately 110.000 Lifelines participants.