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cohort [2020/11/17 08:53] – [Table] trynkecohort [2025/07/24 14:52] (current) – [Subcohorts] laura
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 ====== General Cohort & Factsheets ====== ====== General Cohort & Factsheets ======
  
-The general cohort of [[Start|Lifelines]] consists of 167.729 participants, identified with a Lifelines-ID.\\ +The general population cohort of [[Start|Lifelines]] consists of 167.729 participants, identified with a Lifelines-ID.\\ 
  
 ===== Recruitment ===== ===== Recruitment =====
  
 Lifelines participants were initially recruited through general practitioners in the three provinces in the [[location|northern part of the Netherlands]]: Groningen, Friesland and Drenthe((Scholtens, S., Smidt, N., Swertz, M.A., Bakker, S.J.L., Dotinga, A., Vonk, J.M., van Dijk, F., van Zon, S.K.R., Wijmenga, C., Wolffenbuttel, B.H.R., et al. (2015). Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44, 1172–1180)).\\  Lifelines participants were initially recruited through general practitioners in the three provinces in the [[location|northern part of the Netherlands]]: Groningen, Friesland and Drenthe((Scholtens, S., Smidt, N., Swertz, M.A., Bakker, S.J.L., Dotinga, A., Vonk, J.M., van Dijk, F., van Zon, S.K.R., Wijmenga, C., Wolffenbuttel, B.H.R., et al. (2015). Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44, 1172–1180)).\\ 
-General practitioners invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\ +General practitioners (GP's) invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\ 
 These individuals were then asked to invite their family members (parents, partner, children, parents-in-law), resulting in an additional ~64.500 participants at [[1A|baseline]].\\  These individuals were then asked to invite their family members (parents, partner, children, parents-in-law), resulting in an additional ~64.500 participants at [[1A|baseline]].\\ 
 ~21.500 interested individuals registered directly for [[1A|baseline]] participation via the Lifelines website. ~21.500 interested individuals registered directly for [[1A|baseline]] participation via the Lifelines website.
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 Most questionnaires and measurements are performed in both sexes.\\  Most questionnaires and measurements are performed in both sexes.\\ 
 Notable exceptions: Notable exceptions:
-  * [[ROAQ]], an [[additional assessments|additional assessment]] aimed at women +  * [[ROAQ]], an [[additional assessments|additional assessment]] on reproductive health in women 
-  * [[VESP]], an [[additional assessments|additional assessment]] aimed at men+  * [[VESP]], an [[additional assessments|additional assessment]] on semen quality in men
   * [[NEXT]], our birth cohort with an emphasis on pregnant women (but fathers are also included)   * [[NEXT]], our birth cohort with an emphasis on pregnant women (but fathers are also included)
 Thus far, the *binary* gender of participants was assessed via self-report and via [[https://www.government.nl/topics/personal-data/personal-records-database-brp|BRP]] linkage.\\  Thus far, the *binary* gender of participants was assessed via self-report and via [[https://www.government.nl/topics/personal-data/personal-records-database-brp|BRP]] linkage.\\ 
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 | Only the father          | ~350   | ~250                            | ~80    | ~10   | <10  | <10  | | Only the father          | ~350   | ~250                            | ~80    | ~10   | <10  | <10  |
 | Mother and father        | ~5000  | ~2600                           | ~2000  | ~350  | ~40  | <10  | | Mother and father        | ~5000  | ~2600                           | ~2000  | ~350  | ~40  | <10  |
 +
 +Other family connections (e.g. grandparent-grandchild, siblings) are present in the cohort as well.
  
  
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   * [[DAG3]] subcohort (9,500 participants with extensive metabolomics/microbiomics)   * [[DAG3]] subcohort (9,500 participants with extensive metabolomics/microbiomics)
  
 +{{ :omics.jpg?400 |}}
 ===== Data Linkage ===== ===== Data Linkage =====
  
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   * Individual data from **governmental registries** (i.e. causes of death, socio-economic data) can  be linked to Lifelines health-related data via [[http://www.cbs.nl/microdata|Statistics Netherlands]]   * Individual data from **governmental registries** (i.e. causes of death, socio-economic data) can  be linked to Lifelines health-related data via [[http://www.cbs.nl/microdata|Statistics Netherlands]]
   * Individual results from **pathological tests** (i.e. biopsies) can be linked to Lifelines health-related data (including self-reported [[cancer]]) via [[https://www.palga.nl|PALGA]] and [[https://www.zorgttp.nl|ZorgTTP]]   * Individual results from **pathological tests** (i.e. biopsies) can be linked to Lifelines health-related data (including self-reported [[cancer]]) via [[https://www.palga.nl|PALGA]] and [[https://www.zorgttp.nl|ZorgTTP]]
-  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]]+  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]] (the {{ ::pharmlines_procedures_20210415.pdf|Pharmlines}} initiative). Data on prescription medication can be linked for approximately 110.000 Lifelines participants.
  
  
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