Differences

This shows you the differences between two versions of the page.

--- cohort [2020/08/03 11:18] – trynke
+++ cohort [2026/09/23 09:53] (current) – trynke
@@ Line 1: / Line 1: @@
 ====== General Cohort & Factsheets ======
-The general cohort of [[Start|Lifelines]] consists of 167.729 participants, identified with a Lifelines-ID.\\
+The general population cohort of [[Start|Lifelines]] consists of 167.729 participants, identified with a Lifelines-ID.\\
 ===== Recruitment =====
 Lifelines participants were initially recruited through general practitioners in the three provinces in the [[location|northern part of the Netherlands]]: Groningen, Friesland and Drenthe((Scholtens, S., Smidt, N., Swertz, M.A., Bakker, S.J.L., Dotinga, A., Vonk, J.M., van Dijk, F., van Zon, S.K.R., Wijmenga, C., Wolffenbuttel, B.H.R., et al. (2015). Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44, 1172–1180)).\\
-General practitioners invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\
+General practitioners (GP's) invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\
 These individuals were then asked to invite their family members (parents, partner, children, parents-in-law), resulting in an additional ~64.500 participants at [[1A|baseline]].\\
 ~21.500 interested individuals registered directly for [[1A|baseline]] participation via the Lifelines website.
@@ Line 36: / Line 36: @@
 Most questionnaires and measurements are performed in both sexes.\\
 Notable exceptions:
-  * [[ROAQ]], an [[additional assessments|additional assessment]] aimed at women
+  * [[ROAQ]], an [[additional assessments|additional assessment]] on reproductive health in women
-  * [[VESP]], an [[additional assessments|additional assessment]] aimed at men
+  * [[VESP]], an [[additional assessments|additional assessment]] on semen quality in men
   * [[NEXT]], our birth cohort with an emphasis on pregnant women (but fathers are also included)
 Thus far, the *binary* gender of participants was assessed via self-report and via [[https://www.government.nl/topics/personal-data/personal-records-database-brp|BRP]] linkage.\\
@@ Line 48: / Line 48: @@
 ===== Mortality =====
-To learn more about the Lifelines death rate and causes of death, please see [[mortality|here]].
+Click [[mortality|here]] to learn more about the Lifelines death rate and causes of death.
 ===== Family connections =====
-Lifelines includes many participants with a family connection to one another, including 355 twins and 5 triplets. Current and past family connections between participants are identified using:
+Lifelines includes many participants with a [[family_relations|family connection]] to one another, including 355 twins and 5 triplets. Current and past family connections between participants are identified using:
   * The [[https://www.government.nl/documents/leaflets/2017/01/19/brochure-brp-engelstalig|Dutch citizen registration]]
   * Self-reported information
   * Genotyping (see [[GWAS]] and [[UGLI]])
-Based on BRP and self-report, the following Lifelines [[https://en.wikipedia.org/wiki/Nuclear_family|nuclear families]] can be identified:
-| Number of families       |        ^ Child(ren) = LL Participant(s)                             |||||
-^ Parent = LL participant  | Total  | 1                               | 2      | 3     | 4    | 5    |
-| Mother                   | ~2200  | ~1500                           | ~600   | ~80   | <10  | <10  |
-| Father                   | ~350   | ~250                            | ~80    | ~10   | <10  | <10  |
-| Mother and father        | ~5000  | ~2600                           | ~2000  | ~350  | ~40  | <10  |
 ===== Cohort Facts & Representativity =====
@@ Line 95: / Line 86: @@
   * [[DAG3]] subcohort (9,500 participants with extensive metabolomics/microbiomics)
+{{ :omics.jpg?400 |}}
 ===== Data Linkage =====
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   * Individual data from **governmental registries** (i.e. causes of death, socio-economic data) can  be linked to Lifelines health-related data via [[http://www.cbs.nl/microdata|Statistics Netherlands]]
   * Individual results from **pathological tests** (i.e. biopsies) can be linked to Lifelines health-related data (including self-reported [[cancer]]) via [[https://www.palga.nl|PALGA]] and [[https://www.zorgttp.nl|ZorgTTP]]
-  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]]
+  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]] (the {{ ::pharmlines_procedures_20210415.pdf|Pharmlines}} initiative). Data on prescription medication can be linked for approximately 110.000 Lifelines participants.