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cohort [2020/06/10 16:03]
trynke
cohort [2024/05/16 12:29] (current)
trynke
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 ====== General Cohort & Factsheets ====== ====== General Cohort & Factsheets ======
  
-The general cohort of [[Start|Lifelines]] consists of 167.729 participants,​ identified with a Lifelines-ID.\\ ​+The general ​population ​cohort of [[Start|Lifelines]] consists of 167.729 participants,​ identified with a Lifelines-ID.\\ ​
  
 ===== Recruitment ===== ===== Recruitment =====
  
 Lifelines participants were initially recruited through general practitioners in the three provinces in the [[location|northern part of the Netherlands]]:​ Groningen, Friesland and Drenthe((Scholtens,​ S., Smidt, N., Swertz, M.A., Bakker, S.J.L., Dotinga, A., Vonk, J.M., van Dijk, F., van Zon, S.K.R., Wijmenga, C., Wolffenbuttel,​ B.H.R., et al. (2015). Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44, 1172–1180)).\\ ​ Lifelines participants were initially recruited through general practitioners in the three provinces in the [[location|northern part of the Netherlands]]:​ Groningen, Friesland and Drenthe((Scholtens,​ S., Smidt, N., Swertz, M.A., Bakker, S.J.L., Dotinga, A., Vonk, J.M., van Dijk, F., van Zon, S.K.R., Wijmenga, C., Wolffenbuttel,​ B.H.R., et al. (2015). Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44, 1172–1180)).\\ ​
-General practitioners invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\ ​+General practitioners ​(GP'​s) ​invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\ ​
 These individuals were then asked to invite their family members (parents, partner, children, parents-in-law),​ resulting in an additional ~64.500 participants at [[1A|baseline]].\\ ​ These individuals were then asked to invite their family members (parents, partner, children, parents-in-law),​ resulting in an additional ~64.500 participants at [[1A|baseline]].\\ ​
 ~21.500 interested individuals registered directly for [[1A|baseline]] participation via the Lifelines website. ~21.500 interested individuals registered directly for [[1A|baseline]] participation via the Lifelines website.
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 Most questionnaires and measurements are performed in both sexes.\\ ​ Most questionnaires and measurements are performed in both sexes.\\ ​
 Notable exceptions: Notable exceptions:
-  * [[ROAQ]], an [[additional assessments|additional assessment]] ​aimed at women +  * [[ROAQ]], an [[additional assessments|additional assessment]] ​on reproductive health in women 
-  * [[VESP]], an [[additional assessments|additional assessment]] ​aimed at men+  * [[VESP]], an [[additional assessments|additional assessment]] ​on semen quality in men
   * [[NEXT]], our birth cohort with an emphasis on pregnant women (but fathers are also included)   * [[NEXT]], our birth cohort with an emphasis on pregnant women (but fathers are also included)
 Thus far, the *binary* gender of participants was assessed via self-report and via [[https://​www.government.nl/​topics/​personal-data/​personal-records-database-brp|BRP]] linkage.\\ ​ Thus far, the *binary* gender of participants was assessed via self-report and via [[https://​www.government.nl/​topics/​personal-data/​personal-records-database-brp|BRP]] linkage.\\ ​
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 ===== Mortality ===== ===== Mortality =====
  
-As of July 2019, ~2000 participants have died. Although Lifelines continuously receives updates about the death of participants via the [[https://​www.government.nl/​topics/​personal-data/​personal-records-database-brp|BRP]], we do not know the [[https://​en.wikipedia.org/​wiki/​Cause_of_death|cause of their death]]. Researchers interested in the causes of death may obtain this information via data linkage with [[http://​www.cbs.nl/​microdata|Statistics Netherlands]] +Click [[mortality|here]] to learn more about the Lifelines ​death rate and causes of death. ​  ​
  
 ===== Family connections ===== ===== Family connections =====
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 | Number of families ​      ​| ​       ^ Child(ren) = LL Participant(s) ​                            ||||| | Number of families ​      ​| ​       ^ Child(ren) = LL Participant(s) ​                            |||||
 ^ Parent = LL participant ​ | Total  | 1                               | 2      | 3     | 4    | 5    | ^ Parent = LL participant ​ | Total  | 1                               | 2      | 3     | 4    | 5    |
-Mother ​                  | ~2200  | ~1500                           | ~600   | ~80   | <​10 ​ | <​10 ​ | +Only the mother ​         ​| ~2200  | ~1500                           | ~600   | ~80   | <​10 ​ | <​10 ​ | 
-Father ​                  | ~350   | ~250                            | ~80    | ~10   | <​10 ​ | <​10 ​ |+Only the father ​         ​| ~350   | ~250                            | ~80    | ~10   | <​10 ​ | <​10 ​ |
 | Mother and father ​       | ~5000  | ~2600                           | ~2000  | ~350  | ~40  | <​10 ​ | | Mother and father ​       | ~5000  | ~2600                           | ~2000  | ~350  | ~40  | <​10 ​ |
 +
 +Other family connections (e.g. grandparent-grandchild,​ siblings) are present in the cohort as well.
  
  
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   * Individual data from **governmental registries** (i.e. causes of death, socio-economic data) can  be linked to Lifelines health-related data via [[http://​www.cbs.nl/​microdata|Statistics Netherlands]]   * Individual data from **governmental registries** (i.e. causes of death, socio-economic data) can  be linked to Lifelines health-related data via [[http://​www.cbs.nl/​microdata|Statistics Netherlands]]
   * Individual results from **pathological tests** (i.e. biopsies) can be linked to Lifelines health-related data (including self-reported [[cancer]]) via [[https://​www.palga.nl|PALGA]] and [[https://​www.zorgttp.nl|ZorgTTP]]   * Individual results from **pathological tests** (i.e. biopsies) can be linked to Lifelines health-related data (including self-reported [[cancer]]) via [[https://​www.palga.nl|PALGA]] and [[https://​www.zorgttp.nl|ZorgTTP]]
-  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://​www.iadb.nl|IADB]]+  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://​www.iadb.nl|IADB]] ​(the {{ ::​pharmlines_procedures_20210415.pdf|Pharmlines}} initiative)
  
  
cohort.1591797799.txt.gz · Last modified: 2020/06/10 16:03 by trynke