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====== Additional Assessments ======

On top of the [[general assessments]], additional assessments may be performed in selected groups of Lifelines [[cohort|participants]] (e.g. "subcohorts") in order to collect additional questionnaire data, measurements and/or biomaterials. \\
Additional assessments are performed at the initiative of (and in collaboration with) external research groups, and an embargo period for use of additional data by third parties may apply.\\

The following additional measurements/sample collections have been performed:
  * [[DEEP|DAG1]], a.k.a. **DEEP**, analysis of **microbiome** and methylome in samples of ca. ~1.500 participants
  * [[DAG2]], the assessment of **whole genome** + fecal **microbiome** in samples of ca. 165 participants 
  * [[DAG3]], the assessment of the **microbiome** in samples of ca. ~9.000 participants
  * [[DAG4]], the follow-up to [[DAG3]]
  * [[DAG5]], the follow-up to [[DAG4]]
  * [[EYEL]], the assessment of glaucoma in elderly participants (**EyeLife**)
  * [[GWAS]], the **genotyping** of ~15.000 participants
  * [[UGLI]], the **genotyping** of ~38.500 (UGLI-1) plus ~28,000 (UGLI-2) participants 
  * [[IMAL]], the assessment of CT scans of the lungs & hearts of ~12.000 participants (**ImaLife**)
        * Spin-offs: Biolife, Cardiolife, Memolife 
  * [[MYST]], the use of **quantified-self** devices in ~100 participants
  * [[PGXP]], the use of a **pharmacogenetic passport** in an app by ~1000 participants
  * [[NEXT]], the assessment of ~1500 **pregnant** Lifelines participants (currently an independent project) 
  * [[SALT]], additional urine analyses and questionnaire on salt usage
  * [[SMHD]], the assessment of personal facebook data donated by participants 
  * [[VESP]], the assessment of fertility, sperm quality and plasma hormones in ~200 participants (**Vesper**) 

The following additional questionnaires have been performed:
  * [[ACNQ]], a questionnaire on **acne**  
  * [[ACTQ]], a questionnaire on daily activities and leisure activities (**DALAS**)
  * [[ADHQ]], a questionnaire on **ADHD** and related behavioral problems
  * [[AUTQ]], a questionnaire on **autistic traits**
  * [[BIGQ]], a questionnaire on values and beliefs around **big data** use
  * [[BLUQ]], a questionnaire on children's exposure to **blue light**  
  * [[COVQ]], a series of questionnaires during the **covid-19** pandemic
  * [[DCDQ]], a questionnaire on **motoric** development
  * [[BIONIC|DEPQ]], a questionnaire on lifetime **depression** ([[BIONIC]]-I)
  * [[BIONIC|DEAQ]], a questionnaire on lifetime **depression** and **anxiety** ([[BIONIC]]-II)
  * [[DIVQ]], a questionnaire on well-being and the kinship network after parental divorce
  * [[EARQ]], a questionnaire on experiences with **earthquakes**
  * [[INFQ]], a questionnaire on informal care (**ICAS**)
  * [[MAWQ]], a questionnaire on **menopause** and **work**
  * [[MCFQ]], a questionnaire on myalgic encephalomyelitis/chronic fatigue syndrome
  * [[MHDQ]], a questionnaire on the links between (familial) **mental health** and **diabetes** 
  * [[MUSQ]], a questionnaire on **language** use and **musical** training
  * [[OPBQ]], a questionnaire on **optimism**, parental bonding and emotion regulation
  * [[RELQ]], a questionnaire on the cognitive benefits of **regional language** use
  * [[ROAQ]], a questionnaire on female reproductive health (**ROAHD**)
  * [[SHIQ]], a questionnaire on **shiftwork** and irregular working hours
  * [[SKIQ]], a questionnaire on the **skin conditions** hidradentitis supperative and eczema
  * [[SPEQ]], a questionnaire on **speech, language, and music**
\\

===== Timeline Additional Assesments =====

| **<2012**  |     | [[1A]]  | [[1B]]  |         |         |         |         |         |         |                                                                 |
| **2012**   | q1  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         |                                                                 |
| :::        | q2  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         | [[DEEP]]                                                        |
| :::        | q3  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         | [[DEEP]]                                                        |
| :::        | q4  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         | [[DEEP]]                                                        |
| **2013**   | q1  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         |                                                                 |
| :::        | q2  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         |                                                                 |
| :::        | q3  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         | [[INFQ]]                                                        |
| :::        | q4  | [[1A]]  | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         | [[INFQ]] + [[HAIR]]                                             |
| **2014**   | q1  |         | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         | [[INFQ]]                                                        |
| :::        | q2  |         | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         | [[INFQ]]                                                        |
| :::        | q3  |         | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         |                                                                 |
| :::        | q4  |         | [[1B]]  | [[1C]]  | [[2A]]  |         |         |         |         |                                                                 |
| **2015**   | q1  |         |         | [[1C]]  | [[2A]]  |         |         |         |         |                                                                 |
| :::        | q2  |         |         | [[1C]]  | [[2A]]  |         |         |         |         | [[ACNQ]]                                                        |
| :::        | q3  |         |         | [[1C]]  | [[2A]]  |         |         |         |         | [[DAG3]]                                                        |
| :::        | q4  |         |         | [[1C]]  | [[2A]]  |         |         |         |         | [[DAG3]]                                                        |
| **2016**   | q1  |         |         |         | [[2A]]  | [[2B]]  |         |         |         | [[DAG3]] + [[BIONIC|DEPQ]]                                      |
| :::        | q2  |         |         |         | [[2A]]  | [[2B]]  |         |         |         | [[DAG3]] + [[MYST]]                                             |
| :::        | q3  |         |         |         | [[2A]]  | [[2B]]  |         |         |         | [[DAG3]] + [[MYST]]                                             |
| :::        | q4  |         |         |         | [[2A]]  | [[2B]]  |         |         |         | [[EARQ]]                                                        |
| **2017**   | q1  |         |         |         | [[2A]]  | [[2B]]  |         |         |         |                                                                 |
| :::        | q2  |         |         |         | [[2A]]  | [[2B]]  |         |         |         | [[ADHQ]] + [[DCDQ]] + [[ACTQ]]                                  |
| :::        | q3  |         |         |         | [[2A]]  | [[2B]]  |         |         |         | [[ACTQ]] + [[ROAQ]]                                             |
| :::        | q4  |         |         |         | [[2A]]  | [[2B]]  |         |         |         | [[IMAL]] + [[ACTQ]] + [[ROAQ]] + [[SHIQ]] + [[DIVQ]]            |
| **2018**   | q1  |         |         |         |         | [[2B]]  |         |         |         | [[IMAL]] + [[ACTQ]] + [[ROAQ]] + [[ADHQ]] + [[BLUQ]]+ [[DIVQ]]  |
| :::        | q2  |         |         |         |         | [[2B]]  |         |         |         | [[IMAL]] + [[BLUQ]] + [[BIONIC|DEAQ]] + [[DIVQ]]                |
| :::        | q3  |         |         |         |         | [[2B]]  |         |         |         | [[IMAL]] + [[BIGQ]] + [[BIONIC|DEAQ]] + [[DIVQ]]                |
| :::        | q4  |         |         |         |         | [[2B]]  |         |         |         | [[IMAL]] + [[BIGQ]] + [[DIVQ]]                                  |
| **2019**   | q1  |         |         |         |         | [[2B]]  |         |         |         | [[IMAL]] + [[ADHQ]]+ [[DIVQ]]                                   |
| :::        | q2  |         |         |         |         | [[2B]]  |         |         |         | [[IMAL]]+ [[DIVQ]]                                              |
| :::        | q3  |         |         |         |         | [[2B]]  | [[3A]]  |         |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[AUTQ]]                       |
| :::        | q4  |         |         |         |         | [[2B]]  | [[3A]]  |         |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[MUSQ]]                       |
| **2020**   | q1  |         |         |         |         |         | [[3A]]  |         |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[MUSQ]] + [[SKIQ]]            |
| :::        | q2  |         |         |         |         |         | [[3A]]  |         |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[COVQ]] + [[SKIQ]]            |
| :::        | q3  |         |         |         |         |         | [[3A]]  |         |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[COVQ]]                       |
| :::        | q4  |         |         |         |         |         | [[3A]]  |         |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[COVQ]] + [[SALT]]            |
| **2021**   | q1  |         |         |         |         |         | [[3A]]  |         |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[COVQ]]                       |
|            | q2  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[IMAL]] + [[VESP]] + [[EYEL]] + [[COVQ]] + [[MAWQ]]            |
|            | q3  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[IMAL]] + [[COVQ]] + [[RELQ]]                                  |
|            | q4  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[IMAL]] + [[COVQ]]                                             |
| **2022**   | q1  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[IMAL]] + [[COVQ]]                                             |
|            | q2  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[IMAL]] + [[COVQ]]                                             |
|            | q3  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[IMAL]] + [[COVQ]] + [[SPEQ]]                                  |
|            | q4  |         |         |         |         |         | [[3A]]  | [[3B]]  |         |                                                                 |
| **2023**   | q1  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[MHDQ]]                                                        |
|            | q2  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[MHDQ]]                                                        |
|            | q3  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[OPBQ]]                                                        |
|            | q4  |         |         |         |         |         | [[3A]]  | [[3B]]  |         | [[OPBQ]] + [[MCFQ]]                                             |
| **2024**   | q1  |         |         |         |         |         |         | [[3B]]  | [[4A]]  | [[MCFQ]]                                                        |
|            | q2  |         |         |         |         |         |         | [[3B]]  | [[4A]]  | [[PGXP]]                                                        |
|            | q3  |         |         |         |         |         |         | [[3B]]  | [[4A]]  | [[SMHD]]                                                        |
|            |     |         |         |         |         |         |         |         |         |                                                                 |
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