skin_autofluorescence
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skin_autofluorescence [2020/05/18 09:56] trynke |
skin_autofluorescence [2025/02/05 14:49] (current) |
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| ====== Skin Autofluorescence ====== | ====== Skin Autofluorescence ====== | ||
| - | Skin [[https://en.wikipedia.org/wiki/Autofluorescence|autofluorescence]] (SAF) was measured in ~76,000 adult [[start|Lifelines]] participants during [[1A Visit 1]] in order to determine the level of [[https://en.wikipedia.org/wiki/Advanced_glycation_end-product|Advanced Glycation Endproducts]] (AGEs) using the [[https://www.diagnoptics.com/nl/age-reader|AGE Reader]] device ([[sections|section]]: [[physical state]]). Increased AGE levels are associated with ageing and development of several chronic diseases such as diabetes, renal insufficiency, and cardiovascular disease. | + | Skin [[https://en.wikipedia.org/wiki/Autofluorescence|autofluorescence]] (SAF) ([[sections|section]]: [[physical state]]) was measured in adult [[start|Lifelines]] participants during [[1A Visit 1]] (n = ~84.000, n = ~76,000 after rigorous quality control). |
| ===== Background ===== | ===== Background ===== | ||
| - | AGEs are glycated proteins or lipids as a result of exposure to sugars (the [[https://en.wikipedia.org/wiki/Maillard_reaction|Maillard reaction]]). The presence of AGEs increases the level of SAF, and indeed SAF levels are increased in patients with diabetes, renal failure and in patients with vascular complications. Moreover, SAF is strongly related to the progression of coronary heart disease and mortality, independently of traditional risk factors.\\ | + | SAF was measured in Lifelines participants using the [[https://www.diagnoptics.com/nl/age-reader|AGE Reader]], a noninvasive instrument to determine the accumulation of [[https://en.wikipedia.org/wiki/Advanced_glycation_end-product|Advanced Glycation Endproducts]] (AGEs) in the skin of the forearm.\\ |
| - | The AGE-Reader is a noninvasive instrument to measure AGE accumulation in the human skin of the forearm, using the characteristic autofluorescence pattern that AGEs encompass. SAF-derived AGE values appear to be good predictors of long-term vascular complications in diabetes and in other conditions associated with AGE accumulation ((Mulder DJ et al. (2006). Skin autofluorescence, a novel marker for glycemic and oxidative stress-derived advanced glycation endproducts: an overview of current clinical studies, evidence, and limitations. Diabetes Technology & Therapeutics 8(5):523-535))((Bos DC et al. (2011) Diabetes Technology & Therapeutics 13(7):773-779)).\\ | + | Increased AGE levels are associated with ageing and development of several chronic diseases such as diabetes, renal insufficiency, and cardiovascular disease.AGEs are glycated proteins or lipids as a result of exposure to sugars (the [[https://en.wikipedia.org/wiki/Maillard_reaction|Maillard reaction]]). The presence of AGEs increases the level of SAF, and indeed SAF levels are increased in patients with diabetes, renal failure and in patients with vascular complications. Moreover, SAF is strongly related to the progression of coronary heart disease and mortality, independently of traditional risk factors.\\ |
| + | In general, SAF-derived AGE values appear to be good predictors of long-term vascular complications in diabetes and in other conditions associated with AGE accumulation((Mulder DJ et al. (2006). Skin autofluorescence, a novel marker for glycemic and oxidative stress-derived advanced glycation endproducts: an overview of current clinical studies, evidence, and limitations. Diabetes Technology & Therapeutics 8(5):523-535))((Bos DC et al. (2011) Diabetes Technology & Therapeutics 13(7):773-779)).\\ | ||
| ===== Validation ===== | ===== Validation ===== | ||
skin_autofluorescence.1589788605.txt.gz · Last modified: 2025/02/05 14:49 (external edit)
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