scalp_hair
Differences
This shows you the differences between two versions of the page.
| Both sides previous revision Previous revision Next revision | Previous revision | ||
|
scalp_hair [2019/11/14 17:09] trynke |
— (current) | ||
|---|---|---|---|
| Line 1: | Line 1: | ||
| - | ====== Scalp Hair ====== | ||
| - | Scalp hair samples were collected from ~59,000 adult [[start|Lifelines]] participants during [[2A Visit 2]]. The main aim of hair collection was to use the samples for the assessment of hormone levels, e.g. [[https://en.wikipedia.org/wiki/Cortisol|cortisol]] ([[sections|section]]:[[physical state]]).\\ | ||
| - | The hair collection protocol was piloted in a subcohort of 300 participants in september 2013 (during [[1A Visit 2]]) as an [[additional assessments|additional assessment]] initiated by researchers at the [[https://www6.erasmusmc.nl/roar/departments/internal-medicine|Department of Internal Medicine]] of Erasmus University, the Netherlands. | ||
| - | |||
| - | ===== Background ===== | ||
| - | Cortisol levels are typically assessed in serum, saliva, or urine samples. However, due to the circadian rhythm of cortisol, its pulsatile secretion, and the daily variation due to changing circumstances like acute stress, these samples provide non-representative snapshots of chronic cortisol levels in the human body. | ||
| - | For that reason, a novel non-invasive parameter to measure cortisol using scalp hair was developed((Manenschijn L et al. (2011). Evaluation of a method to measure long term cortisol levels. Steroids 76(10-11):1032-1036)), providing the unique opportunity to measure long-term cortisol levels that reflect the mean levels of several months (since hair grows with an average of 1 cm per month). Using this technique, it is now possible to study chronic cortisol levels over time in very large cohorts((Russell E. et al (2015). Toward standardization of hair cortisol measurement: results of the first international interlaboratory round robin. Therapeutic Drug Monitoring 37(1):71-75)). | ||
| - | |||
| - | ===== Protocol ===== | ||
| - | During [[2A visit 2]], participants were asked to provide a lock of hair. Nurse practitioners that assisted in the visit cut off a lock of hair close to the scalp using clean scissors. The lock of hair was placed in an envelope, clearly marked and registered, and stored at room temperature.\\ | ||
| - | Participants also filled in a questionnaire about their hair. See the list of questions below. | ||
| - | |||
| - | ===== Publications using Lifelines hair samples ===== | ||
| - | - Wester et al. (2017) Hair analysis reveals subtle HPA axis suppression associated with use of local corticosteroids: The Lifelines cohort study. Psychoneuroendocrinology 80: 1-6 | ||
| - | - van Manen et al. (2019) Scalp hair cortisol and testosterone levels in patients with sarcoidosis. Plos ONE 14(6): e0215763 | ||
| - | - Savas et al. (2019) Hair glucocorticoids as biomarker for endogenous Cushing's syndrome: validation in two independent cohorts. Neuroendocrinology 109(2):171-178 | ||
| - | |||
| - | ===== Questionnaire ===== | ||
| - | Participants provided the following information about their hair via a questionnaire: | ||
| - | |||
| - | | **Questions English** | **Questions Dutch** | **Variable** | **Assessment** | **Age** | | ||
| - | | What is your natural hair colour at the moment? | Wat is op dit moment uw natuurlijke haarkleur? | HAIR1 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | How often do you wash your hair a week? | Hoe vaak wast u uw haren per week? | HAIR2 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Do you regularly perspire very heavily on your head, for instance when you are playing sports, in the sauna or for some other reason? | Transpireert u regelmatig zeer hevig op het hoofd, bijvoorbeeld tijdens het sporten, tijdens een bezoek aan de sauna of vanwege een andere reden? | HAIR3 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Average number of days a month of severe perspiration of the head. | Gemiddeld aantal dagen per maand zeer hevig transpireren op het hoofd. | HAIR3A | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Have you used some form of corticosteroids (e.g. prednisone tablets, nasal spray, puffs, infusion, injection or skin creams) in the past three months? | Hebt u in de afgelopen 3 maanden een vorm van corticosteroïden (bv. prednisontabletten, neusspray, longpufjes, infuus, injectie of huidcremès) gebruikt? | HAIR4 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | How were the corticosteroids administered? | Hoe werden de corticosteroïden toegediend? | | | | | ||
| - | | Tablets or capsules | Tabletten of capsules / | HAIR4A1 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Infusion | Infuus / Hoe werden de corticosteroïden toegediend? | HAIR4A2 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Injection into joint, e.g. wrist, shoulder or knee | Injectie in een gewricht, bv. in pols, schouder of knie / Hoe werden de corticosteroïden toegediend? | HAIR4A3 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Puffs (inhalation medication) | Pufjes (inhalatiemedicatie) / Hoe werden de corticosteroïden toegediend? | HAIR4A4 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Nasal spray | Neusspray / Hoe werden de corticosteroïden toegediend? | HAIR4A5 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Cream or ointment | Crème of zalf / Hoe werden de corticosteroïden toegediend? | HAIR4A6 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | If cream or ointment; Where? | Indien crème of zalf. Waar? | HAIR4A6A | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Other: | Anders, nl. / Hoe werden de corticosteroïden toegediend? | HAIR4A7 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Has your hair been dyed, coloured, bleached or permanent-waved or did you have highlights or lowlights during the past six months? | Is uw haar geverfd, gekleurd, geblondeerd of gepermanent in de laatste 6 maanden of heeft u in deze periode highlights, lowlights of coupe soleil laten zetten? | HAIR5 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Bleaching / What treatment did your hair have in the past six months? | Blonderen / Welke behandeling heeft uw haar gehad in de laatste 6 maanden? | HAIR5A | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | When did you last bleach your hair? | Wanneer heeft u voor het laatst uw haar geblondeerd? | HAIR5A1 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Highlights, lowlights / What treatment did your hair have in the past six months? | Highlights, lowlights of coupe soleil / Welke behandeling heeft uw haar gehad in de laatste 6 maanden? | HAIR5B | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | When did you last have highlights or lowlights? | Wanneer heeft u voor het laatst highlights, lowlights of coupe soleil laten zetten? | HAIR5B1 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Colouring with permanent dye / What treatment did your hair have in the past six months? | Verven met permanente verf / Welke behandeling heeft uw haar gehad in de laatste 6 maanden? | HAIR5C | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | When did you last colour your hair using permanent dye? | Wanneer heeft u voor het laatst uw haar geverfd met permanente verf? | HAIR5C1 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Colouring with semi-permanent dye What treatment did your hair have in the past six months? | Kleuren met kleurspoeling / Welke behandeling heeft uw haar gehad in de laatste 6 maanden? | HAIR5D | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | When did you last colour your hair using semi-permanent dye? | Wanneer heeft u voor het laatst uw haar geverfd met kleurspoeling? | HAIR5D1 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | Permanent wave / What treatment did your hair have in the past six months? | Permanenten / Welke behandeling heeft uw haar gehad in de laatste 6 maanden? | HAIR5E | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | When did yo last have a permanent wave? | Wanneer heeft u voor het laatst uw haar gepermanent? | HAIR5E1 | [[2A Questionnaire 2|2A]] | 18+ | | ||
| - | | | Hebt u sinds de laatste keer dat u uw haar hebt gewassen een haarproduct gebruikt? | HAIR6 | Pilot | 18+ | | ||
| - | | | Welk haarproduct hebt u gebruikt?: Mousse | HAIR6A | Pilot | 18+ | | ||
| - | | | Welk haarproduct hebt u gebruikt?: Gel | HAIR6B | Pilot | 18+ | | ||
| - | | | Welk haarproduct hebt u gebruikt?: Wax | HAIR6C | Pilot | 18+ | | ||
| - | | | Welk haarproduct hebt u gebruikt?: Haarlak | HAIR6D | Pilot | 18+ | | ||
| - | | | Welk haarproduct hebt u gebruikt?: Anders, nl. | HAIR6E | Pilot | 18+ | | ||
scalp_hair.1573747746.txt.gz · Last modified: 2025/02/05 14:49 (external edit)
Page Tools
Except where otherwise noted, content on this wiki is licensed under the following license: CC Attribution-Noncommercial-Share Alike 4.0 International
