scalp_hair
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| - | ====== Scalp Hair ====== | ||
| - | Scalp hair samples were collected from ~59,000 adult [[start|Lifelines]] participants during [[2A Visit 2]]. The main aim of hair collection was to use the samples for the assessment of hormone levels, e.g. [[https:// | ||
| - | The hair collection protocol was piloted in a subcohort of 300 participants in september 2013 (during [[1A Visit 2]]) as an [[additional assessments|additional assessment]] initiated by researchers at the [[https:// | ||
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| - | ===== Background ===== | ||
| - | Cortisol levels are typically assessed in serum, saliva, or urine samples. However, due to the circadian rhythm of cortisol, its pulsatile secretion, and the daily variation due to changing circumstances like acute stress, these samples provide non-representative snapshots of chronic cortisol levels in the human body. | ||
| - | For that reason, a novel non-invasive parameter to measure cortisol using scalp hair was developed ((Manenschijn L et al. (2011). Evaluation of a method to measure long term cortisol levels. Steroids 76(10-11): | ||
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| - | ===== Protocol ===== | ||
| - | During [[2A visit 2]], participants were asked to provide a lock of hair. Nurse practitioners that assisted in the visit cut off a lock of hair close to the scalp using clean scissors. The lock of hair was placed in an envelope, clearly marked and registered, and stored at room temperature.\\ | ||
| - | Participants also filled in a questionnaire about their hair. See the list of questions below. | ||
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| - | ===== Publications using Lifelines hair samples ===== | ||
| - | - Wester et al. (2017) Hair analysis reveals subtle HPA axis suppression associated with use of local corticosteroids: | ||
| - | - van Manen et al. (2019) Scalp hair cortisol and testosterone levels in patients with sarcoidosis. Plos ONE 14(6): e0215763 | ||
| - | - Savas et al. (2019) Hair glucocorticoids as biomarker for endogenous Cushing' | ||
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| - | ===== Questionnaire ===== | ||
| - | Participants provided the following information about their hair via a questionnaire: | ||
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| - | | **Questions English** | ||
| - | | What is your natural hair colour at the moment? | ||
| - | | How often do you wash your hair a week? | Hoe vaak wast u uw haren per week? | HAIR2 | [[2A Questionnaire 2|2A]] | ||
| - | | Do you regularly perspire very heavily on your head, for instance when you are playing sports, in the sauna or for some other reason? | ||
| - | | Average number of days a month of severe perspiration of the head. | Gemiddeld aantal dagen per maand zeer hevig transpireren op het hoofd. | ||
| - | | Have you used some form of corticosteroids (e.g. prednisone tablets, nasal spray, puffs, infusion, injection or skin creams) in the past three months? | ||
| - | | How were the corticosteroids administered? | ||
| - | | Tablets or capsules | ||
| - | | Infusion | ||
| - | | Injection into joint, e.g. wrist, shoulder or knee | Injectie in een gewricht, bv. in pols, schouder of knie / Hoe werden de corticosteroïden toegediend? | ||
| - | | Puffs (inhalation medication) | ||
| - | | Nasal spray | Neusspray / Hoe werden de corticosteroïden toegediend? | ||
| - | | Cream or ointment | ||
| - | | If cream or ointment; Where? | ||
| - | | Other: | ||
| - | | Has your hair been dyed, coloured, bleached or permanent-waved or did you have highlights or lowlights during the past six months? | ||
| - | | Bleaching / What treatment did your hair have in the past six months? | ||
| - | | When did you last bleach your hair? | Wanneer heeft u voor het laatst uw haar geblondeerd? | ||
| - | | Highlights, lowlights / What treatment did your hair have in the past six months? | ||
| - | | When did you last have highlights or lowlights? | ||
| - | | Colouring with permanent dye / What treatment did your hair have in the past six months? | ||
| - | | When did you last colour your hair using permanent dye? | Wanneer heeft u voor het laatst uw haar geverfd met permanente verf? | HAIR5C1 | ||
| - | | Colouring with semi-permanent dye What treatment did your hair have in the past six months? | ||
| - | | When did you last colour your hair using semi-permanent dye? | Wanneer heeft u voor het laatst uw haar geverfd met kleurspoeling? | ||
| - | | Permanent wave / What treatment did your hair have in the past six months? | ||
| - | | When did yo last have a permanent wave? | Wanneer heeft u voor het laatst uw haar gepermanent? | ||
| - | | | Hebt u sinds de laatste keer dat u uw haar hebt gewassen een haarproduct gebruikt? | ||
| - | | | Welk haarproduct hebt u gebruikt?: Mousse | ||
| - | | | Welk haarproduct hebt u gebruikt?: Gel | HAIR6B | ||
| - | | | Welk haarproduct hebt u gebruikt?: Wax | HAIR6C | ||
| - | | | Welk haarproduct hebt u gebruikt?: Haarlak | ||
| - | | | Welk haarproduct hebt u gebruikt?: Anders, nl. | HAIR6E | ||
scalp_hair.1571228891.txt.gz · Last modified: (external edit)