User Tools

Site Tools


deep

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
Next revision
Previous revision
deep [2020/06/09 13:55]
sylvia [Data availability]
deep [2024/10/03 17:17] (current)
trynke
Line 1: Line 1:
 ====== DEEP/DAG1 ====== ====== DEEP/DAG1 ======
-Lifelines-DEEP,​ also known as DAG1, is one of [[start|Lifelines]]'​ [[additional assessments]] performed in collaboration with the UMCG [[https://​www.systemsgenetics.nl/​|department of genetics]] (see also: [[DAG2]] and [[DAG3]]). DAG is the abbreviation of DArmGezondheid,​ or "​Gastrointestinal health"​ in Dutch, a research project in which the microbiome is analysed in [[faecal analyses|faecal samples]].\\+Lifelines-DEEP,​ also known as DAG1, is one of [[start|Lifelines]]'​ [[additional assessments]] performed in collaboration with the UMCG [[https://​www.systemsgenetics.nl/​|department of genetics]] (see also: [[DAG2]] and [[DAG3]]). DAG is the abbreviation of DArmGezondheid,​ or "​Gastrointestinal health"​ in Dutch, a research project in which the microbiome is analysed in faecal samples.\\
 The primary goal of the Lifelines-DEEP project is to get insight in the relations between [[https://​en.wikipedia.org/​wiki/​Genome|genome]],​ [[https://​en.wikipedia.org/​wiki/​epigenome|epigenome]],​ [[https://​en.wikipedia.org/​wiki/​Transcriptome|transcriptome]],​ [[https://​en.wikipedia.org/​wiki/​microbiome|microbiome]],​ [[https://​en.wikipedia.org/​wiki/​metabolome|metabolome]],​ and other biological and phenotypic parameters. Lifelines-DEEP is an example of a ‘next- generation’ population cohort study—in which multiple molecular data levels are combined with observational research methods ((Tigchelaar EF et al. (2015) Cohort profile: LifeLines DEEP, a prospective,​ general population cohort study in the northern Netherlands:​ study design and baseline characteristics. BMJ Open 5(8): e006772)) The primary goal of the Lifelines-DEEP project is to get insight in the relations between [[https://​en.wikipedia.org/​wiki/​Genome|genome]],​ [[https://​en.wikipedia.org/​wiki/​epigenome|epigenome]],​ [[https://​en.wikipedia.org/​wiki/​Transcriptome|transcriptome]],​ [[https://​en.wikipedia.org/​wiki/​microbiome|microbiome]],​ [[https://​en.wikipedia.org/​wiki/​metabolome|metabolome]],​ and other biological and phenotypic parameters. Lifelines-DEEP is an example of a ‘next- generation’ population cohort study—in which multiple molecular data levels are combined with observational research methods ((Tigchelaar EF et al. (2015) Cohort profile: LifeLines DEEP, a prospective,​ general population cohort study in the northern Netherlands:​ study design and baseline characteristics. BMJ Open 5(8): e006772))
  
 ===== Subcohort ===== ===== Subcohort =====
  
-From April to August 2013, all adult participants registered at the Lifelines location in Groningen were invited to participate in Lifelines-DEEP,​ in addition to the regular Lifelines programme. Inclusion stopped when the target group size of n=~1500 was reached.+From April 2012 to August 2013, all adult participants registered at the Lifelines location in Groningen were invited to participate in Lifelines-DEEP,​ in addition to the regular Lifelines programme. Inclusion stopped when the target group size of n=~1500 was reached.
  
 ===== Protocol ===== ===== Protocol =====
Line 17: Line 17:
  
 ===== Data availability ===== ===== Data availability =====
-^ Type           ​^ N            ^ Available? ​        ​+^ Type                ^ N         ​^ Available? ​ 
-| Genomics ​      ​| +/- 1400     ​| Yes                +| Genomics ​(cytosnp)  ​| +/- 1400  | Yes         ​
-| Methylation ​   | +/- 800      | Yes                +| Methylation ​        ​| +/- 800   ​| Yes         ​
-| RNAseq ​        ​| +/- 50       | Yes                +| RNAseq ​             | +/- 1300  ​| Yes         ​
-| MGS            | +/- 1200     ​| Yes                +| MGS                 ​| +/- 1200  | Yes*        ​
-| 16S            | +/- 1000     ​| Yes                +| 16S                 ​| +/- 1000  | Yes*        ​
-| Metabolomics ​  ​| -            No                 +| Metabolomics ​       +/1400  ​Yes         | 
-| Proteomics ​    ​| -            No                 |+| Cytokines ​          | +/- 1100  | Yes         
 +| Proteomics ​         +/1100  ​Yes         | 
 +| WES                 | +/- 1000  | Yes         | 
 +*Raw data is available; the processed data is not available yet
  
 ===== Genomics ===== ===== Genomics =====
deep.1591703741.txt.gz · Last modified: 2020/06/09 13:55 by sylvia